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    wde windei [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36133, updated on 10-May-2024

    Summary

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    Official Symbol
    wdeprovided by FlyBase
    Official Full Name
    windeiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027499
    Locus tag
    Dmel_CG12340
    See related
    AllianceGenome:FB:FBgn0027499
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD26050; CG12340; Dmel\CG12340; i10; i119; LD26050; Wde; WDE
    Summary
    Predicted to enable transcription coregulator activity. Involved in positive regulation of DNA methylation-dependent heterochromatin assembly. Located in chromosome. Is expressed in several structures, including central nervous system; embryonic/larval gut; extended germ band embryo; gonad; and ring gland. Orthologous to several human genes including ATF7IP (activating transcription factor 7 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See wde in Genome Data Viewer
    Location:
    47C1-47C1; 2-63 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10800420..10808938, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6687925..6696443, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44301 Neighboring gene methuselah-like 13 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nop10 ribonucleoprotein Neighboring gene Methyl methanesulfonate sensitivity 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chorion formation in panoistic ovaries requires windei and trimethylation of histone 3 lysine 9. Herraiz A, et al. Exp Cell Res, 2014 Jan 1. PMID 23872316
    2. Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing. Osumi K, et al. EMBO Rep, 2019 Dec 5. PMID 31576653, Free PMC Article
    3. wde, calpA, if, dap160, and poe genes knock down Drosophila models exhibit neurofunctional deficit. Haddadi M, et al. Gene, 2022 Jun 30. PMID 35447243
    4. Drosophila Heterochromatin Stabilization Requires the Zinc-Finger Protein Small Ovary. Benner L, et al. Genetics, 2019 Nov. PMID 31558581, Free PMC Article
    5. The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells. Smolko AE, et al. Nat Commun, 2018 Oct 8. PMID 30297796, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In ovarian somatic cells, Egg is monoubiquitinated and phosphorylated but only monoubiquitination is required for piRNA-mediated transposon repression. Egg monoubiquitination occurs in the nucleus. Egg has its own nuclear localization signal, and the nuclear import of Egg is Wde-independent. Wde recruits Egg to the chromatin at target gene silencing loci, but their interaction is monoubiquitin-independent.
      Title: Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing.
    2. Windei and H3K9me3 have already been reported in follicular cells of D. melanogaster, but this is the first time that the function of these modifications has been demonstrated in the said cells.
      Title: Chorion formation in panoistic ovaries requires windei and trimethylation of histone 3 lysine 9.
    3. Together with Egg, Wde (Windei) localizes to euchromatin, is enriched on chromosome 4, and binds to the Painting of fourth (POF) protein.
      Title: Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c10802093-10801962 mobile_element_type = transposon:INE-1{}4241

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA methylation-dependent heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA methylation-dependent heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    windei
    Names
    CG12340-PA
    CG12340-PB
    wde-PA
    wde-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10800420..10808938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136764.3 → NP_610608.1  windei, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMH9
      Related
      FBpp0087348
      Conserved Domains (1) summary
      pfam16794
      Location:1320 → 1418
      fn3_4; Fibronectin-III type domain

    2. NM_001299365.1 → NP_001286294.1  windei, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286294.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMH9
      Conserved Domains (1) summary
      pfam16794
      Location:1320 → 1418
      fn3_4; Fibronectin-III type domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KMH9 Q7KMH9

    Gene LinkOut

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