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    Prl2c1 Prolactin family 2, subfamily c, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 666317, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Prl2c1provided by MGI
    Official Full Name
    Prolactin family 2, subfamily c, member 1provided by MGI
    Primary source
    MGI:MGI:3649927
    See related
    Ensembl:ENSMUSG00000062551 AllianceGenome:MGI:3649927
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ghd22
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including positive regulation of lactation; positive regulation of pri-miRNA transcription by RNA polymerase II; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward placenta adult (RPKM 40.2) See more
    Orthologs
    all
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    Genomic context

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    Location:
    13 A3.1; 13 12.63 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (28033324..28041774)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27849341..27857791)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 7, subfamily c, member 1 Neighboring gene prolactin family 2, subfamily a, member 1 Neighboring gene predicted gene, 22476 Neighboring gene predicted gene, 34165 Neighboring gene preferentially expressed antigen in melanoma-like pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bridging sequence diversity and tissue-specific expression by DNA methylation in genes of the mouse prolactin superfamily. Hayakawa K, et al. Mamm Genome, 2012 Jun. PMID 22193412, Free PMC Article
    2. Curated eutherian third party data gene data sets. Premzl M. Data Brief, 2016 Mar. PMID 26862561, Free PMC Article
    3. Third party data gene data set of eutherian growth hormone genes. Premzl M. Genom Data, 2015 Dec. PMID 26697363, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Prolactin family 2, subfamily c, member 1
    Names
    growth hormone d22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045532.2 → NP_001038997.1  Prolactin family 2, subfamily c, member 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL627326
      Consensus CDS
      CCDS36626.1
      UniProtKB/TrEMBL
      Q5SVM0
      Related
      ENSMUSP00000053446.6, ENSMUST00000054932.13
      Conserved Domains (1) summary
      pfam00103
      Location:33 → 226
      Hormone_1; Somatotropin hormone family

    2. NM_001361045.1 → NP_001347974.1  Prolactin family 2, subfamily c, member 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL627326
      Consensus CDS
      CCDS88433.1
      UniProtKB/TrEMBL
      Q5SVL9
      Related
      ENSMUSP00000105964.3, ENSMUST00000110335.10
      Conserved Domains (1) summary
      pfam00103
      Location:24 → 228
      Hormone_1; Somatotropin hormone family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      28033324..28041774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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