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    MAG1 DNA-3-methyladenine glycosylase II [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856885, updated on 13-Apr-2024

    Summary

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    Gene symbol
    MAG1
    Gene description
    DNA-3-methyladenine glycosylase II
    Primary source
    SGD:S000000944
    Locus tag
    YER142C
    See related
    AllianceGenome:SGD:S000000944
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MMS5
    Summary
    Enables DNA-3-methyladenine glycosylase activity and damaged DNA binding activity. Involved in DNA dealkylation involved in DNA repair and base-excision repair, AP site formation. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (455146..456036, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Emp65p Neighboring gene Cox15p Neighboring gene Ddi1p Neighboring gene putative ubiquitin-specific protease UBP5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Harnessing mutagenic homologous recombination for targeted mutagenesis in vivo by TaGTEAM. Finney-Manchester SP, et al. Nucleic Acids Res, 2013 May. PMID 23470991, Free PMC Article
    2. Substrate specificity and sequence-dependent activity of the Saccharomyces cerevisiae 3-methyladenine DNA glycosylase (Mag). Lingaraju GM, et al. DNA Repair (Amst), 2008 Jun 1. PMID 18472311, Free PMC Article
    3. Effects of substrate specificity on initiating the base excision repair of N-methylpurines by variant human 3-methyladenine DNA glycosylases. Connor EE, et al. Chem Res Toxicol, 2005 Jan. PMID 15651853
    4. Generation of a strong mutator phenotype in yeast by imbalanced base excision repair. Glassner BJ, et al. Proc Natl Acad Sci U S A, 1998 Aug 18. PMID 9707589, Free PMC Article
    5. Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase. Matijasevic Z, et al. Proc Natl Acad Sci U S A, 1993 Dec 15. PMID 8265637, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA-3-methyladenine glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-3-methyladenine glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-3-methyladenine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-3-methylguanine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-7-methyladenine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-7-methylguanine glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-7-methylguanine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alkylated DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkylbase DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alkylbase DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA alkylation repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA alkylation repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair, AP site formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair, AP site formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair, AP site formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in base-excision repair, AP site formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-3-methyladenine glycosylase II
    NP_011069.1
    • 3-methyl-adenine DNA glycosylase; initiates base excision repair (BER) by removing damaged bases to create abasic sites that are subsequently repaired; expansion of BER repair removes alkylated bases resulting from alkylating agent-induced DNA damage, compensating for the lack of DNA repair by oxidative dealkylation; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      455146..456036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179032.1 → NP_011069.1  TPA: DNA-3-methyladenine glycosylase II [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011069.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM49, P22134
      UniProtKB/TrEMBL
      A0A6V8S7I3, A6ZR99, B3LRQ5, B5VHR7, C7GQ54, C8Z7G2, N1P763
      Conserved Domains (1) summary
      COG0122
      Location:1 → 291
      AlkA; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22134.1

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