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    GSTO2 glutathione S-transferase omega 2 [ Homo sapiens (human) ]

    Gene ID: 119391, updated on 3-Apr-2024

    Summary

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    Official Symbol
    GSTO2provided by HGNC
    Official Full Name
    glutathione S-transferase omega 2provided by HGNC
    Primary source
    HGNC:HGNC:23064
    See related
    Ensembl:ENSG00000065621 MIM:612314; AllianceGenome:HGNC:23064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GSTO 2-2; bA127L20.1
    Summary
    The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
    Expression
    Broad expression in skin (RPKM 2.1), testis (RPKM 1.8) and 21 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    10q25.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (104269184..104304950)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (105157320..105193113)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (106028942..106064708)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902497 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106013818-106014332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3979 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3983 Neighboring gene glutathione S-transferase omega 1 Neighboring gene microRNA 4482 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:106058991-106060190 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:106060509-106061008 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106075123-106075652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106075653-106076181 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:106078667-106079168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106083478-106084208 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106084209-106084937 Neighboring gene inositol 1,4,5-trisphosphate receptor interacting protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106086727-106087372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106087373-106088018 Neighboring gene ITPRIP antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106089957-106090602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106090603-106091248 Neighboring gene Sharpr-MPRA regulatory region 8343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3984 Neighboring gene Sharpr-MPRA regulatory region 11867 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2799 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:106109241-106110165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3989 Neighboring gene cilia and flagella associated protein 58 Neighboring gene CFAP58 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The GSTO2 (rs156697) Polymorphism Modifies Diabetic Nephropathy Risk. Pavlovic D, et al. Medicina (Kaunas), 2023 Jan 13. PMID 36676788, Free PMC Article
    2. Loss of GSTO2 contributes to cell growth and mitochondria function via the p38 signaling in lung squamous cell carcinoma. Sumiya R, et al. Cancer Sci, 2022 Jan. PMID 34726807, Free PMC Article
    3. Glutathione S-transferase Omega 2 DD genotype is associated with an increased risk of sporadic amyotrophic lateral sclerosis in Chinese men. Fan Z, et al. J Int Med Res, 2021 Jul. PMID 34311603, Free PMC Article
    4. Glutathione S-transferase O2 gene rs157077 polymorphism predicts response to transarterial chemoembolization in hepatocellular carcinoma. Wang Z, et al. Tumour Biol, 2015 Aug. PMID 25835968
    5. Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation. Stamenkovic M, et al. Clin Exp Ophthalmol, 2014 Apr. PMID 23927022

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The GSTO2 (rs156697) Polymorphism Modifies Diabetic Nephropathy Risk.
      Title: The GSTO2 (rs156697) Polymorphism Modifies Diabetic Nephropathy Risk.
    2. Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma.
      Title: Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma.
    3. Loss of GSTO2 contributes to cell growth and mitochondria function via the p38 signaling in lung squamous cell carcinoma.
      Title: Loss of GSTO2 contributes to cell growth and mitochondria function via the p38 signaling in lung squamous cell carcinoma.
    4. Glutathione S-transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir.
      Title: Glutathione S-transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir.
    5. Glutathione S-transferase Omega 2 DD genotype is associated with an increased risk of sporadic amyotrophic lateral sclerosis in Chinese men.
      Title: Glutathione S-transferase Omega 2 DD genotype is associated with an increased risk of sporadic amyotrophic lateral sclerosis in Chinese men.
    6. Glutathione S-transferase omega 2 regulates cell growth and the expression of E-cadherin via post-transcriptional down-regulation of beta-catenin in human esophageal squamous cells.
      Title: Glutathione S-transferase omega 2 regulates cell growth and the expression of E-cadherin via post-transcriptional down-regulation of β-catenin in human esophageal squamous cells.
    7. GSTO2 variant showed lower values of induced DNA damage in chronic kidney disease.
      Title: Levels of DNA damage (Micronuclei) in patients suffering from chronic kidney disease. Role of GST polymorphisms.
    8. No direct association between different genotypes and the alleles of the GSTO1 and GSTO2 genes and risk of ischemic stroke in a Turkish population.
      Title: Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population.
    9. the effect of specific GSTO1 and GSTO2 gene variants, independently and in interaction with established risk factors (smoking, obesity and hypertension) on the risk for the most aggressive renal cell carcinoma (RCC) subtype, the clear cell RCC, is reported.
      Title: Concomitance of Polymorphisms in Glutathione Transferase Omega Genes Is Associated with Risk of Clear Cell Renal Cell Carcinoma.
    10. Results showed that the variants of rs156697 and rs2297235 of GSTO2 provide the susceptibility toward developing arsenic-induced skin lesions in individuals exposed to high-dose inorganic arsenic in northwest China.
      Title: Association between arsenic metabolism gene polymorphisms and arsenic-induced skin lesions in individuals exposed to high-dose inorganic arsenic in northwest China.
    Submit: New GeneRIF Correction See all GeneRIFs (57)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutathione dehydrogenase (ascorbate) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione dehydrogenase (ascorbate) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables methylarsonate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-ascorbic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-ascorbic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to arsenic-containing substance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    glutathione S-transferase omega-2
    Names
    GSTO-2
    MMA(V) reductase
    bA127L20.1 (novel glutathione-S-transferase)
    glutathione S-transferase omega 2-2
    glutathione-S-transferase-like protein
    glutathione-dependent dehydroascorbate reductase
    monomethylarsonic acid reductase
    NP_001177942.1
    NP_001177943.1
    NP_001177944.1
    NP_899062.1
    XP_011537574.1
    XP_016871160.1
    XP_047280533.1
    XP_047280534.1
    XP_054220719.1
    XP_054220720.1
    XP_054220721.1
    XP_054220722.1
    XP_054220723.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023363.2 RefSeqGene

      Range
      5002..40768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001191013.2 → NP_001177942.1  glutathione S-transferase omega-2 isoform 2

      See identical proteins and their annotated locations for NP_001177942.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL162742, BC056918, DC341647
      Consensus CDS
      CCDS53574.1
      UniProtKB/Swiss-Prot
      Q9H4Y5
      Related
      ENSP00000390986.2, ENST00000450629.6
      Conserved Domains (3) summary
      COG0625
      Location:26 → 177
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cl00388
      Location:7 → 94
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:108 → 196
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. NM_001191014.2 → NP_001177943.1  glutathione S-transferase omega-2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to isoform 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL162742, BC046194, BC056918
      Consensus CDS
      CCDS53575.1
      UniProtKB/Swiss-Prot
      Q9H4Y5
      Related
      ENSP00000358721.1, ENST00000369707.2
      Conserved Domains (3) summary
      cd03184
      Location:80 → 202
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      COG0625
      Location:4 → 183
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cl00388
      Location:1 → 66
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. NM_001191015.2 → NP_001177944.1  glutathione S-transferase omega-2 isoform 4

      See identical proteins and their annotated locations for NP_001177944.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence, and lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus and lacks an internal segment compared to isoform 1.
      Source sequence(s)
      AL162742, BC046194, BC056918, BM708208
      UniProtKB/Swiss-Prot
      Q9H4Y5
      Conserved Domains (3) summary
      COG0625
      Location:4 → 149
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cl00388
      Location:1 → 66
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:80 → 168
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    4. NM_183239.2 → NP_899062.1  glutathione S-transferase omega-2 isoform 1

      See identical proteins and their annotated locations for NP_899062.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL162742, BC056918
      Consensus CDS
      CCDS7556.1
      UniProtKB/Swiss-Prot
      A8K771, B4DJW6, E7ESD6, Q49TW5, Q5GM70, Q5JU15, Q86WP3, Q9H4Y5
      Related
      ENSP00000345023.1, ENST00000338595.7
      Conserved Domains (2) summary
      cd03184
      Location:108 → 230
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cl00388
      Location:7 → 94
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      104269184..104304950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424577.1 → XP_047280533.1  glutathione S-transferase omega-2 isoform X1

    2. XM_047424578.1 → XP_047280534.1  glutathione S-transferase omega-2 isoform X3

    3. XM_011539272.4 → XP_011537574.1  glutathione S-transferase omega-2 isoform X2

      See identical proteins and their annotated locations for XP_011537574.1

      Conserved Domains (3) summary
      COG0625
      Location:26 → 120
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cl00388
      Location:7 → 94
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:108 → 166
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    4. XM_017015671.2 → XP_016871160.1  glutathione S-transferase omega-2 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      105157320..105193113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364744.1 → XP_054220719.1  glutathione S-transferase omega-2 isoform X1

    2. XM_054364746.1 → XP_054220721.1  glutathione S-transferase omega-2 isoform X3

    3. XM_054364745.1 → XP_054220720.1  glutathione S-transferase omega-2 isoform X2

      UniProtKB/TrEMBL
      B4DU59

    4. XM_054364748.1 → XP_054220723.1  glutathione S-transferase omega-2 isoform X4

    5. XM_054364747.1 → XP_054220722.1  glutathione S-transferase omega-2 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H4Y5.1 GenPept UniProtKB/Swiss-Prot:Q9H4Y5

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