U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    MKS1 Mks1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855648, updated on 3-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MKS1
    Official Full Name
    Mks1p
    Primary source
    SGD:S000005020
    Locus tag
    YNL076W
    See related
    AllianceGenome:SGD:S000005020; FungiDB:YNL076W; VEuPathDB:YNL076W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LYS80
    Summary
    Involved in several processes, including mitochondria-nucleus signaling pathway; negative regulation of transcription by RNA polymerase II; and regulation of pseudohyphal growth. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MKS1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (483556..485310)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Nis1p Neighboring gene Apj1p Neighboring gene snoRNA-binding rRNA-processing protein IMP4 Neighboring gene Mlf3p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mutation affecting the specific regulatory control of lysine biosynthetic enzymes in Saccharomyces cerevisiae. Ramos F, et al. Mol Gen Genet, 1985. PMID 3929019
    2. Nitrogen source and the retrograde signalling pathway affect detection, not generation, of the [URE3] prion. Edskes HK, et al. Yeast, 2006 Aug. PMID 16921555
    3. Interaction between Rtg2p and Mks1p in the regulation of the RTG pathway of Saccharomyces cerevisiae. Ferreira Júnior JR, et al. Gene, 2005 Jul 18. PMID 15967597
    4. Lys80p of Saccharomyces cerevisiae, previously proposed as a specific repressor of LYS genes, is a pleiotropic regulatory factor identical to Mks1p. Feller A, et al. Yeast, 1997 Nov. PMID 9392078
    5. Mitochondrial Retrograde Signaling Contributes to Metabolic Differentiation in Yeast Colonies. Plocek V, et al. Int J Mol Sci, 2021 May 25. PMID 34070491, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that dynamic association between Mks1p and Rtg2p in high molecular weight complexes provides a means to regulate the RTG pathway.
      Title: Interaction between Rtg2p and Mks1p in the regulation of the RTG pathway of Saccharomyces cerevisiae.
    2. Tor signaling and Mks1p phosphorylation regulate expression of Rtg1.Rtg3p-dependent target genes
      Title: Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1.Rtg3p-dependent target genes.
    3. Mks1p is a central player of retrograde signaling (RS) and is acted upon by multiple regulators of the pathway.
      Title: A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondria-nucleus signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondria-nucleus signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nitrogen utilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of nitrogen utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Mks1p
    NP_014323.1
    • Pleiotropic negative transcriptional regulator; involved in Ras-cAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      483556..485310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182914.1 → NP_014323.1  TPA: Mks1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014323.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1A3, P34072, Q02533
      UniProtKB/TrEMBL
      B3LNT5, C8ZGF4, N1NXZ2
      Conserved Domains (1) summary
      pfam08550
      Location:37 → 64
      DUF1752; Fungal protein of unknown function (DUF1752)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34072.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools