Format

Send to:

Choose Destination
    • Showing Current items.

    SERP2 stress associated endoplasmic reticulum protein family member 2 [ Homo sapiens (human) ]

    Gene ID: 387923, updated on 7-Dec-2018

    Summary

    Official Symbol
    SERP2provided by HGNC
    Official Full Name
    stress associated endoplasmic reticulum protein family member 2provided by HGNC
    Primary source
    HGNC:HGNC:20607
    See related
    Ensembl:ENSG00000151778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C13orf21; bA269C23.1
    Expression
    Broad expression in brain (RPKM 17.7), testis (RPKM 10.7) and 16 other tissues See more
    Orthologs

    Genomic context

    See SERP2 in Genome Data Viewer
    Location:
    13q14.11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (44373523..44397714)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (44947978..44971850)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984552 Neighboring gene uncharacterized LOC105370297 Neighboring gene tumor suppressor candidate 8 Neighboring gene TSC22 domain family member 1 Neighboring gene TSC22D1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC35505

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    stress-associated endoplasmic reticulum protein 2
    Names
    ribosome-associated membrane protein RAMP4-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010897.3NP_001010897.1  stress-associated endoplasmic reticulum protein 2

      See identical proteins and their annotated locations for NP_001010897.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer protein coding transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL138960, BC029067
      Consensus CDS
      CCDS31965.1
      UniProtKB/Swiss-Prot
      Q8N6R1
      Related
      ENSP00000368477.3, ENST00000379179.7
      Conserved Domains (1) summary
      pfam06624
      Location:258
      RAMP4; Ribosome associated membrane protein RAMP4
    2. NM_001346980.1NP_001333909.1  stress-associated endoplasmic reticulum protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL138960
      Consensus CDS
      CCDS31965.1
      UniProtKB/Swiss-Prot
      Q8N6R1
      Conserved Domains (1) summary
      pfam06624
      Location:258
      RAMP4; Ribosome associated membrane protein RAMP4

    RNA

    1. NR_144535.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL138960

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      44373523..44397714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449348.1XP_024305116.1  stress-associated endoplasmic reticulum protein 2 isoform X1

      Conserved Domains (1) summary
      pfam06624
      Location:252
      RAMP4; Ribosome associated membrane protein RAMP4
    2. XM_024449349.1XP_024305117.1  stress-associated endoplasmic reticulum protein 2 isoform X1

      Conserved Domains (1) summary
      pfam06624
      Location:252
      RAMP4; Ribosome associated membrane protein RAMP4
    3. XM_024449351.1XP_024305119.1  stress-associated endoplasmic reticulum protein 2 isoform X1

      Conserved Domains (1) summary
      pfam06624
      Location:252
      RAMP4; Ribosome associated membrane protein RAMP4
    4. XM_024449352.1XP_024305120.1  stress-associated endoplasmic reticulum protein 2 isoform X1

      Related
      ENSP00000435473.1, ENST00000493476.1
      Conserved Domains (1) summary
      pfam06624
      Location:252
      RAMP4; Ribosome associated membrane protein RAMP4
    5. XM_024449350.1XP_024305118.1  stress-associated endoplasmic reticulum protein 2 isoform X1

      Conserved Domains (1) summary
      pfam06624
      Location:252
      RAMP4; Ribosome associated membrane protein RAMP4
    Support Center