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    SmD1 Small ribonucleoprotein particle protein SmD1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44668, updated on 5-May-2024

    Summary

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    Official Symbol
    SmD1provided by FlyBase
    Official Full Name
    Small ribonucleoprotein particle protein SmD1provided by FlyBase
    Primary source
    FLYBASE:FBgn0261933
    Locus tag
    Dmel_CG10753
    See related
    AllianceGenome:FB:FBgn0261933
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE39488; CG10753; D1-Sm; dD1; Dmel\CG10753; l(2)SH3 003; l(3)SH003; smd1; snRNP; snRNP-69D; snRNP69D
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Located in nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including central nervous system and extended germ band embryo. Human ortholog(s) of this gene implicated in connective tissue disease; nephritis; proteinuria; and systemic lupus erythematosus. Orthologous to human SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    69D6-69D6; 3-38 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12733364..12734611, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12726464..12727711, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44552 Neighboring gene mirror Neighboring gene Protein tyrosine phosphatase 69D Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Association of the neuron-specific RNA binding domain-containing protein ELAV with the coiled body in Drosophila neurons. Yannoni YM, et al. Chromosoma, 1997 Apr. PMID 9087375
    2. Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Desai CJ, et al. Cell, 1996 Feb 23. PMID 8598046
    3. Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster. Azzouz TN, et al. RNA, 2003 Dec. PMID 14624008, Free PMC Article
    4. Polypeptide components of Drosophila small nuclear ribonucleoprotein particles. Paterson T, et al. Nucleic Acids Res, 1991 Nov 11. PMID 1834995, Free PMC Article
    5. Precursor RNA processing 3 is required for male fertility, and germline stem cell self-renewal and differentiation via regulating spliceosome function in Drosophila testes. Chen X, et al. Sci Rep, 2019 Jul 10. PMID 31292463, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal snRNP assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SMN-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of commitment complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of pICln-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small nuclear ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of spliceosomal tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small ribonucleoprotein particle protein SmD1
    Names
    CG10753-PA
    SmD1-PA
    lethal (3) SH003
    small nuclear ribonucleoprotein at 69D

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12733364..12734611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080035.3 → NP_524774.1  small ribonucleoprotein particle protein SmD1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524774.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3DML3, Q8SYR6, Q9VU02
      Related
      FBpp0075684
      Conserved Domains (1) summary
      cd01724
      Location:2 → 93
      Sm_D1; Sm protein D1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VU02.1 Q9VU02

    Gene LinkOut

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