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    FCRL1 Fc receptor like 1 [ Homo sapiens (human) ]

    Gene ID: 115350, updated on 5-Mar-2024

    Summary

    Official Symbol
    FCRL1provided by HGNC
    Official Full Name
    Fc receptor like 1provided by HGNC
    Primary source
    HGNC:HGNC:18509
    See related
    Ensembl:ENSG00000163534 MIM:606508; AllianceGenome:HGNC:18509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FCRH1; IFGP1; IRTA5; CD307a
    Summary
    This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
    Expression
    Biased expression in lymph node (RPKM 18.4), spleen (RPKM 14.4) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FCRL1 in Genome Data Viewer
    Location:
    1q23.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (157794403..157820120, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (156931472..156957188, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157764193..157789910, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene voltage dependent anion channel 1 pseudogene 9 Neighboring gene Fc receptor like 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:157739405-157740604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1895 Neighboring gene CD5 molecule like Neighboring gene mitochondrial ribosomal protein S21 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp667O1421

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables coreceptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Fc receptor-like protein 1
    Names
    IFGP family protein 1
    fc receptor homolog 1
    fcR-like protein 1
    hIFGP1
    immune receptor translocation-associated protein 5
    immunoglobulin superfamily Fc receptor, gp42

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159397.2NP_001152869.1  Fc receptor-like protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001152869.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region compared to variant 1, that results in a frameshift. This variant encodes isoform 2, which is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK096690, AL356276, AL833674, DA939902
      Consensus CDS
      CCDS53382.1
      UniProtKB/Swiss-Prot
      Q96LA6
      Related
      ENSP00000351039.3, ENST00000358292.7
      Conserved Domains (3) summary
      smart00410
      Location:119201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207280
      Ig_3; Immunoglobulin domain
    2. NM_001159398.2NP_001152870.1  Fc receptor-like protein 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001152870.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AF329488, AL356276, AL833674, DA939902
      Consensus CDS
      CCDS53383.1
      UniProtKB/Swiss-Prot
      Q96LA6
      Related
      ENSP00000418130.1, ENST00000491942.1
      Conserved Domains (3) summary
      smart00410
      Location:119201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207280
      Ig_3; Immunoglobulin domain
    3. NM_052938.5NP_443170.1  Fc receptor-like protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_443170.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL356276, AL833674, AY043464, DA939902
      Consensus CDS
      CCDS1170.1
      UniProtKB/Swiss-Prot
      B2RE05, Q8N759, Q8NDI0, Q96LA6, Q96PJ6
      Related
      ENSP00000357158.3, ENST00000368176.8
      Conserved Domains (3) summary
      smart00410
      Location:119201
      IG_like; Immunoglobulin like
      pfam13895
      Location:1990
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207280
      Ig_3; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      157794403..157820120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005244869.4XP_005244926.1  Fc receptor-like protein 1 isoform X11

      Conserved Domains (2) summary
      smart00410
      Location:23105
      IG_like; Immunoglobulin like
      pfam13927
      Location:111184
      Ig_3; Immunoglobulin domain
    2. XM_011509134.3XP_011507436.1  Fc receptor-like protein 1 isoform X9

      See identical proteins and their annotated locations for XP_011507436.1

      Conserved Domains (3) summary
      smart00410
      Location:44126
      IG_like; Immunoglobulin like
      pfam13895
      Location:40126
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:132205
      Ig_3; Immunoglobulin domain
    3. XM_011509127.3XP_011507429.1  Fc receptor-like protein 1 isoform X3

      Conserved Domains (3) summary
      smart00410
      Location:112194
      IG_like; Immunoglobulin like
      pfam13895
      Location:108194
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:200273
      Ig_3; Immunoglobulin domain
    4. XM_011509135.3XP_011507437.1  Fc receptor-like protein 1 isoform X10

      Conserved Domains (2) summary
      smart00410
      Location:30112
      IG_like; Immunoglobulin like
      pfam13927
      Location:118191
      Ig_3; Immunoglobulin domain
    5. XM_011509133.3XP_011507435.1  Fc receptor-like protein 1 isoform X9

      See identical proteins and their annotated locations for XP_011507435.1

      Conserved Domains (3) summary
      smart00410
      Location:44126
      IG_like; Immunoglobulin like
      pfam13895
      Location:40126
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:132205
      Ig_3; Immunoglobulin domain
    6. XM_005244867.3XP_005244924.1  Fc receptor-like protein 1 isoform X8

      Related
      ENST00000489998.5
      Conserved Domains (3) summary
      smart00410
      Location:119201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207280
      Ig_3; Immunoglobulin domain
    7. XM_011509130.2XP_011507432.1  Fc receptor-like protein 1 isoform X7

      Conserved Domains (3) summary
      smart00410
      Location:119201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207280
      Ig_3; Immunoglobulin domain
    8. XM_005244866.3XP_005244923.1  Fc receptor-like protein 1 isoform X6

      Conserved Domains (3) summary
      smart00410
      Location:119201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207280
      Ig_3; Immunoglobulin domain
    9. XM_011509129.2XP_011507431.1  Fc receptor-like protein 1 isoform X5

      Conserved Domains (3) summary
      smart00410
      Location:119201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207280
      Ig_3; Immunoglobulin domain
    10. XM_011509128.2XP_011507430.1  Fc receptor-like protein 1 isoform X4

      Conserved Domains (3) summary
      smart00410
      Location:119201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207280
      Ig_3; Immunoglobulin domain
    11. XM_011509126.2XP_011507428.1  Fc receptor-like protein 1 isoform X2

      Conserved Domains (3) summary
      smart00410
      Location:119201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207280
      Ig_3; Immunoglobulin domain
    12. XM_011509125.2XP_011507427.1  Fc receptor-like protein 1 isoform X1

      Conserved Domains (3) summary
      smart00410
      Location:119201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207280
      Ig_3; Immunoglobulin domain
    13. XM_047444001.1XP_047299957.1  Fc receptor-like protein 1 isoform X13

    14. XM_011509136.2XP_011507438.1  Fc receptor-like protein 1 isoform X12

      Conserved Domains (3) summary
      smart00410
      Location:119201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207280
      Ig_3; Immunoglobulin domain

    RNA

    1. XR_921738.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      156931472..156957188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334157.1XP_054190132.1  Fc receptor-like protein 1 isoform X11

    2. XM_054334155.1XP_054190130.1  Fc receptor-like protein 1 isoform X9

    3. XM_054334148.1XP_054190123.1  Fc receptor-like protein 1 isoform X3

    4. XM_054334156.1XP_054190131.1  Fc receptor-like protein 1 isoform X10

    5. XM_054334154.1XP_054190129.1  Fc receptor-like protein 1 isoform X9

    6. XM_054334153.1XP_054190128.1  Fc receptor-like protein 1 isoform X8

    7. XM_054334152.1XP_054190127.1  Fc receptor-like protein 1 isoform X7

    8. XM_054334151.1XP_054190126.1  Fc receptor-like protein 1 isoform X6

    9. XM_054334150.1XP_054190125.1  Fc receptor-like protein 1 isoform X5

    10. XM_054334149.1XP_054190124.1  Fc receptor-like protein 1 isoform X4

    11. XM_054334147.1XP_054190122.1  Fc receptor-like protein 1 isoform X2

    12. XM_054334146.1XP_054190121.1  Fc receptor-like protein 1 isoform X1

    13. XM_054334159.1XP_054190134.1  Fc receptor-like protein 1 isoform X13

    14. XM_054334158.1XP_054190133.1  Fc receptor-like protein 1 isoform X12

    RNA

    1. XR_008485907.1 RNA Sequence