H15 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: H15provided by FlyBase
Primary source: FLYBASE:FBgn0016660
Locus tag: Dmel_CG6604
See related: AllianceGenome:FB:FBgn0016660
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6604; dm-H15; Dm-H15; Dmel\CG6604; nmr; Nmr; Nmr-1; nmr1; Nmr1; nmr[H15]; Tbx20
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; chorion-containing eggshell pattern formation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including circulatory system; cuboidal/columnar epithelium; embryonic dorsal vessel; embryonic/larval nervous system; and neuroblast of ventral nervous system. Used to study cardiomyopathy and congenital heart disease. Human ortholog(s) of this gene implicated in atrial heart septal defect 4. Orthologous to human TBX20 (T-box transcription factor 20). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 25E1-25E1; 2-17 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5404280..5416593)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5404280..5416593)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that midline protein (mid) and H15 protein (H15) specify ventral fate through inhibition of decapentaplegic protein (Dpp) signaling and through coordinating the repression of genes in the ventral leg.
Title: The selector genes midline and H15 control ventral leg pattern by both inhibiting Dpp signaling and specifying ventral fate.
Results suggest that midline and H15 may be considered as the selector genes for ventral leg fate.
Title: The Tbx20 homologs midline and H15 specify ventral fate in the Drosophila melanogaster leg.
Nmr1 and nmr2 appear to act together as members of the combinatorial code of transcription factors that govern neuronal subtype identity in the central nervous system.
Title: Neuromancer1 and Neuromancer2 regulate cell fate specification in the developing embryonic CNS of Drosophila melanogaster.
nmr is a gene required in adult fly hearts for the maintenance of both normal myofibrillar architecture and cardiac physiology.
Title: Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease.
H15 participates in cardiac fate specification and may normally act redundantly with other cardiogenic factors.
Title: The Drosophila melanogaster T-box genes midline and H15 are conserved regulators of heart development.
In odd-numbered abdominal segments, Mid/H15 activity plays an important role in restricting the expression of Wg to a single domain.
Title: Drosophila T box proteins break the symmetry of hedgehog-dependent activation of wingless.
one of the major functions of mid and H15 during cardioblast development is the re-activation of tin expression at a stage when the induction of tin by Dpp in the dorsal mesoderm has ceased
Title: Tbx20-related genes, mid and H15, are required for tinman expression, proper patterning, and normal differentiation of cardioblasts in Drosophila.
Data suggest that neuromancer 1 and 2 act both in concert with and subsequent to pannier and tinman in cardiac specification and differentiation.
Title: Neuromancer Tbx20-related genes (H15/midline) promote cell fate specification and morphogenesis of the Drosophila heart.
The function of the HI5 protein in Drosophila melanogaster neurogensis is described.
Title: Functions of the segment polarity genes midline and H15 in Drosophila melanogaster neurogenesis.
In odd-numbered abdominal segments, Mid and H15 activity plays an important role in restricting the expression of Wg to a single domain.
Title: Drosophila T box proteins break the symmetry of hedgehog-dependent activation of wingless.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardioblast cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in chorion-containing eggshell pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart process	IDA Inferred from Direct Assay more info	PubMed
involved_in leg disc pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: H15

Names: CG6604-PA; CG6604-PB; H15-PA; H15-PB; neuromancer; neuromancer 1; neuromancer 2; neuromancer-1; neuromancer1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

5404280..5416593

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_135082.3 → NP_608926.2 H15, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608926.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94890, Q9VMR3

Related

FBpp0078710

Conserved Domains (1) summary

cd00182
Location:276 → 475

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
NM_001298698.1 → NP_001285627.1 H15, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285627.1

Status: REVIEWED

UniProtKB/TrEMBL

X2J9F2

Conserved Domains (1) summary

cd00182
Location:275 → 474

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...