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    Dgcr8 DGCR8, microprocessor complex subunit [ Mus musculus (house mouse) ]

    Gene ID: 94223, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dgcr8provided by MGI
    Official Full Name
    DGCR8, microprocessor complex subunitprovided by MGI
    Primary source
    MGI:MGI:2151114
    See related
    Ensembl:ENSMUSG00000022718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N4; Gy1; N41; D16Wi; Vo59c; D16Wis2; Vo59c07; mir-1306; D16H22S788; D16H22S788E; D16H22S1742E
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.0), CNS E14 (RPKM 9.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dgcr8 in Genome Data Viewer
    Location:
    16 A3; 16 11.31 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18071812..18107115, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18253948..18289251, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (18254057..18289261, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene zinc finger, DHHC domain containing 8 Neighboring gene predicted gene, 25777 Neighboring gene RAN binding protein 1 Neighboring gene TRM2 tRNA methyltransferase 2A Neighboring gene microRNA 1306 Neighboring gene microRNA 3618 Neighboring gene transport and golgi organization 2 Neighboring gene microRNA 185 Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome Neighboring gene catechol-O-methyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables primary miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables primary miRNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables primary miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-RNA adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in primary miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of microprocessor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of microprocessor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    microprocessor complex subunit DGCR8
    Names
    DiGeorge syndrome critical region gene 8
    diGeorge syndrome critical region 8 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033324.2NP_201581.2  microprocessor complex subunit DGCR8

      See identical proteins and their annotated locations for NP_201581.2

      Status: VALIDATED

      Source sequence(s)
      AB086857
      Consensus CDS
      CCDS28018.1
      UniProtKB/Swiss-Prot
      Q9EQM6
      Related
      ENSMUSP00000009321.5, ENSMUST00000009321.11
      Conserved Domains (3) summary
      smart00456
      Location:302332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:618686
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      18071812..18107115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522795.3XP_006522858.1  microprocessor complex subunit DGCR8 isoform X1

      See identical proteins and their annotated locations for XP_006522858.1

      Conserved Domains (3) summary
      smart00456
      Location:302332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:639707
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
    2. XM_030249355.2XP_030105215.1  microprocessor complex subunit DGCR8 isoform X2

      Conserved Domains (3) summary
      smart00456
      Location:302332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:618686
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
    3. XM_030249354.2XP_030105214.1  microprocessor complex subunit DGCR8 isoform X1

      Conserved Domains (3) summary
      smart00456
      Location:302332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:639707
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
    4. XM_030249352.1XP_030105212.1  microprocessor complex subunit DGCR8 isoform X1

      Conserved Domains (3) summary
      smart00456
      Location:302332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:639707
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
    5. XM_030249353.1XP_030105213.1  microprocessor complex subunit DGCR8 isoform X1

      Conserved Domains (3) summary
      smart00456
      Location:302332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:639707
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
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