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    Dgcr8 DGCR8, microprocessor complex subunit [ Mus musculus (house mouse) ]

    Gene ID: 94223, updated on 31-Jan-2019

    Summary

    Official Symbol
    Dgcr8provided by MGI
    Official Full Name
    DGCR8, microprocessor complex subunitprovided by MGI
    Primary source
    MGI:MGI:2151114
    See related
    Ensembl:ENSMUSG00000022718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gy1; N41; D16Wis2; Vo59c07; mir-1306; D16H22S788E; D16H22S1742E
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.0), CNS E14 (RPKM 9.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dgcr8 in Genome Data Viewer
    Location:
    16 A3; 16 11.31 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (18253948..18289255, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (18254057..18289261, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene zinc finger, DHHC domain containing 8 Neighboring gene RAN binding protein 1 Neighboring gene TRM2 tRNA methyltransferase 2A Neighboring gene microRNA 1306 Neighboring gene predicted gene, 24572 Neighboring gene transport and golgi organization 2 Neighboring gene microRNA 185 Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome Neighboring gene catechol-O-methyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    primary miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    primary miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ribonuclease III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to ribonuclease III activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    primary miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    microprocessor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microprocessor complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    microprocessor complex subunit DGCR8
    Names
    DiGeorge syndrome critical region gene 8
    diGeorge syndrome critical region 8 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033324.2NP_201581.2  microprocessor complex subunit DGCR8

      See identical proteins and their annotated locations for NP_201581.2

      Status: VALIDATED

      Source sequence(s)
      AB086857
      Consensus CDS
      CCDS28018.1
      UniProtKB/Swiss-Prot
      Q9EQM6
      Related
      ENSMUSP00000009321.4, ENSMUST00000009321.10
      Conserved Domains (2) summary
      smart00456
      Location:302332
      WW; Domain with 2 conserved Trp (W) residues
      pfam00035
      Location:513576
      dsrm; Double-stranded RNA binding motif

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      18253948..18289255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522795.2XP_006522858.1  microprocessor complex subunit DGCR8 isoform X1

      See identical proteins and their annotated locations for XP_006522858.1

      Conserved Domains (2) summary
      smart00456
      Location:302332
      WW; Domain with 2 conserved Trp (W) residues
      pfam00035
      Location:513576
      dsrm; Double-stranded RNA binding motif
    2. XM_017317176.1XP_017172665.1  microprocessor complex subunit DGCR8 isoform X1

      Conserved Domains (2) summary
      smart00456
      Location:302332
      WW; Domain with 2 conserved Trp (W) residues
      pfam00035
      Location:513576
      dsrm; Double-stranded RNA binding motif

    RNA

    1. XR_001781878.1 RNA Sequence

    2. XR_001781873.1 RNA Sequence

    3. XR_001781875.1 RNA Sequence

    4. XR_001781877.1 RNA Sequence

    5. XR_001781876.1 RNA Sequence

    6. XR_001781879.1 RNA Sequence

    7. XR_001781874.1 RNA Sequence

    Reference GRCm38.p4 PATCHES

    Genomic

    1. NW_004450262.1 Reference GRCm38.p4 PATCHES

      Range
      28302..63506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 129S6/SvEvTac

    Genomic

    1. NT_187012.1 Reference GRCm38.p4 129S6/SvEvTac

      Range
      62522..97721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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