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    Dgcr8 DGCR8, microprocessor complex subunit [ Mus musculus (house mouse) ]

    Gene ID: 94223, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dgcr8provided by MGI
    Official Full Name
    DGCR8, microprocessor complex subunitprovided by MGI
    Primary source
    MGI:MGI:2151114
    See related
    Ensembl:ENSMUSG00000022718 AllianceGenome:MGI:2151114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gy1; N41; D16Wis2; Vo59c07; mir-1306; D16H22S788E; D16H22S1742E
    Summary
    Enables primary miRNA binding activity. Acts upstream of or within regulation of stem cell proliferation. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including brain; cardiovascular system; early embryo; facial prominence; and hemolymphoid system. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human DGCR8 (DGCR8 microprocessor complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.0), CNS E14 (RPKM 9.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dgcr8 in Genome Data Viewer
    Location:
    16 A3; 16 11.31 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18071812..18107115, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18253948..18289251, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:18231149-18231350 Neighboring gene zinc finger, DHHC domain containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E8621 Neighboring gene predicted gene, 25777 Neighboring gene RAN binding protein 1 Neighboring gene TRM2 tRNA methyltransferase 2A Neighboring gene STARR-positive B cell enhancer ABC_E1921 Neighboring gene microRNA 1306 Neighboring gene microRNA 3618 Neighboring gene transport and golgi organization 2 Neighboring gene STARR-positive B cell enhancer ABC_E10891 Neighboring gene microRNA 185 Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome Neighboring gene STARR-seq mESC enhancer starr_40280 Neighboring gene catechol-O-methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reduced adult hippocampal neurogenesis and working memory deficits in the Dgcr8-deficient mouse model of 22q11.2 deletion-associated schizophrenia can be rescued by IGF2. Ouchi Y, et al. J Neurosci, 2013 May 29. PMID 23719809, Free PMC Article
    2. Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Rao PK, et al. Circ Res, 2009 Sep 11. PMID 19679836, Free PMC Article
    3. Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation. Bartram MP, et al. BMC Nephrol, 2015 Apr 14. PMID 25881298, Free PMC Article
    4. MicroRNA function is globally suppressed in mouse oocytes and early embryos. Suh N, et al. Curr Biol, 2010 Feb 9. PMID 20116247, Free PMC Article
    5. MicroRNAs are required for the feature maintenance and differentiation of brown adipocytes. Kim HJ, et al. Diabetes, 2014 Dec. PMID 25008181, Free PMC Article

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals.
      Title: Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals.
    2. RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization.
      Title: RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization.
    3. Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells.
      Title: Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells.
    4. The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response.
      Title: The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response.
    5. The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes.
      Title: The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes.
    6. Global miRNA dosage control of embryonic germ layer specification.
      Title: Global miRNA dosage control of embryonic germ layer specification.
    7. DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria.
      Title: DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria.
    8. Different Cre systems induce differential microRNA landscapes and abnormalities in the female reproductive tracts of Dgcr8 conditional knockout mice.
      Title: Different Cre systems induce differential microRNA landscapes and abnormalities in the female reproductive tracts of Dgcr8 conditional knockout mice.
    9. DGCR8 overexpression alleviated hMSC aging and mouse osteoarthritis.
      Title: Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis.
    10. The Ddx6 knockout cells were phenotypically and molecularly similar to cells lacking all microRNAs (Dgcr8 knockout ESCs). These data show that the loss of DDX6 can separate the two canonical functions of microRNAs: translational repression and transcript destabilization
      Title: Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells.
    Submit: New GeneRIF Correction See all GeneRIFs (43)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables primary miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables primary miRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables primary miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-RNA adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-RNA adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of pre-miRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in primary miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    part_of microprocessor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of microprocessor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microprocessor complex subunit DGCR8
    Names
    DiGeorge syndrome critical region gene 8
    diGeorge syndrome critical region 8 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033324.2 → NP_201581.2  microprocessor complex subunit DGCR8

      See identical proteins and their annotated locations for NP_201581.2

      Status: VALIDATED

      Source sequence(s)
      AB086857
      Consensus CDS
      CCDS28018.1
      UniProtKB/Swiss-Prot
      Q9EQM6
      Related
      ENSMUSP00000009321.5, ENSMUST00000009321.11
      Conserved Domains (3) summary
      smart00456
      Location:302 → 332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505 → 578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:618 → 686
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      18071812..18107115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522795.3 → XP_006522858.1  microprocessor complex subunit DGCR8 isoform X1

      See identical proteins and their annotated locations for XP_006522858.1

      Conserved Domains (3) summary
      smart00456
      Location:302 → 332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505 → 578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:639 → 707
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

    2. XM_030249355.2 → XP_030105215.1  microprocessor complex subunit DGCR8 isoform X2

      UniProtKB/Swiss-Prot
      Q9EQM6
      Conserved Domains (3) summary
      smart00456
      Location:302 → 332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505 → 578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:618 → 686
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

    3. XM_030249354.2 → XP_030105214.1  microprocessor complex subunit DGCR8 isoform X1

      Conserved Domains (3) summary
      smart00456
      Location:302 → 332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505 → 578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:639 → 707
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

    4. XM_030249352.1 → XP_030105212.1  microprocessor complex subunit DGCR8 isoform X1

      Conserved Domains (3) summary
      smart00456
      Location:302 → 332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505 → 578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:639 → 707
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

    5. XM_030249353.1 → XP_030105213.1  microprocessor complex subunit DGCR8 isoform X1

      Conserved Domains (3) summary
      smart00456
      Location:302 → 332
      WW; Domain with 2 conserved Trp (W) residues
      cd19867
      Location:505 → 578
      DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
      cd19868
      Location:639 → 707
      DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQM6.2 GenPept UniProtKB/Swiss-Prot:Q9EQM6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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