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    Brwd1 bromodomain and WD repeat domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 93871, updated on 31-Jan-2019

    Summary

    Official Symbol
    Brwd1provided by MGI
    Official Full Name
    bromodomain and WD repeat domain containing 1provided by MGI
    Primary source
    MGI:MGI:1890651
    See related
    Ensembl:ENSMUSG00000022914
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdr9; repro5; G1-403-16; 5330419I02Rik; D530019K20Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 12.4), CNS E11.5 (RPKM 12.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Brwd1 in Genome Data Viewer
    Location:
    16; 16 C4
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (95992089..96082428, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (96213699..96304035, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1600002D24 gene Neighboring gene predicted gene, 41508 Neighboring gene proteasome (prosome, macropain) assembly chaperone 1 Neighboring gene high mobility group nucleosomal binding domain 1 Neighboring gene tryptophan rich basic protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1)  1 citation
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    bromodomain and WD repeat-containing protein 1
    Names
    WD repeat domain 9
    WD repeat-containing protein 9

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103179.1NP_001096649.1  bromodomain and WD repeat-containing protein 1 isoform B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and CDS compared to variant 1. The resulting isoform (B) is shorter and has a unique C-terminus compared to isoform A.
      Source sequence(s)
      AJ292468, AK030493, AK051870, AK162170, CA561282, CF162350, CV558558
      UniProtKB/Swiss-Prot
      Q921C3
      UniProtKB/TrEMBL
      Q3TSA7, Q8BPZ1
      Conserved Domains (5) summary
      cd05496
      Location:13171433
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:11501265
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      COG2319
      Location:181540
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:178497
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:189226
      7WD40; WD40 repeat [structural motif]
    2. NM_145125.3NP_660107.2  bromodomain and WD repeat-containing protein 1 isoform A

      See identical proteins and their annotated locations for NP_660107.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (A).
      Source sequence(s)
      AJ292467, AK027961, AK030493, AK051870, AW542089, CF162350, CV558558
      Consensus CDS
      CCDS49923.1
      UniProtKB/Swiss-Prot
      Q921C3
      UniProtKB/TrEMBL
      Q8BPZ1
      Related
      ENSMUSP00000097101.2, ENSMUST00000099502.8
      Conserved Domains (5) summary
      cd05496
      Location:13171433
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:11501265
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      COG2319
      Location:181540
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:178497
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:189226
      7WD40; WD40 repeat [structural motif]
    3. NM_176928.1NP_795902.1  bromodomain and WD repeat-containing protein 1 isoform C

      See identical proteins and their annotated locations for NP_795902.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and CDS compared to variant 1. The resulting isoform (C) is much shorter and has a unique C-terminus compared to isoform A.
      Source sequence(s)
      AK051870, BB272960
      Consensus CDS
      CCDS49922.1
      UniProtKB/TrEMBL
      Q8BPZ1
      Related
      ENSMUSP00000109458.1, ENSMUST00000113827.3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      95992089..96082428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523113.1XP_006523176.1  bromodomain and WD repeat-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006523176.1

      Conserved Domains (5) summary
      cd05496
      Location:13171433
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:11501265
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      COG2319
      Location:181540
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:178497
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:189226
      7WD40; WD40 repeat [structural motif]
    2. XM_017317169.1XP_017172658.1  bromodomain and WD repeat-containing protein 1 isoform X3

    3. XM_006523114.3XP_006523177.1  bromodomain and WD repeat-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006523177.1

      Conserved Domains (5) summary
      cd05496
      Location:13031419
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:11501265
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      COG2319
      Location:181540
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:178497
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:189226
      7WD40; WD40 repeat [structural motif]
    4. XM_011246157.2XP_011244459.1  bromodomain and WD repeat-containing protein 1 isoform X5

      See identical proteins and their annotated locations for XP_011244459.1

      Related
      ENSMUSP00000023631.8, ENSMUST00000023631.16
      Conserved Domains (5) summary
      cd05496
      Location:13171433
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:11501265
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      COG2319
      Location:181540
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:178497
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:189226
      7WD40; WD40 repeat [structural motif]
    5. XM_011246156.1XP_011244458.1  bromodomain and WD repeat-containing protein 1 isoform X4

      See identical proteins and their annotated locations for XP_011244458.1

      Conserved Domains (5) summary
      cd05496
      Location:9911107
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:824939
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      COG2319
      Location:2217
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:340
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:2217
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. XM_006523115.3XP_006523178.1  bromodomain and WD repeat-containing protein 1 isoform X6

      See identical proteins and their annotated locations for XP_006523178.1

      Conserved Domains (2) summary
      cd05496
      Location:814930
      Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      cd05529
      Location:647762
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    7. XM_017317170.1XP_017172659.1  bromodomain and WD repeat-containing protein 1 isoform X3

    Reference GRCm38.p4 129S6/SvEvTac

    Genomic

    1. NT_187015.1 Reference GRCm38.p4 129S6/SvEvTac

      Range
      145750..236081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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