U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    BOD1 biorientation of chromosomes in cell division 1 [ Homo sapiens (human) ]

    Gene ID: 91272, updated on 17-Jun-2024

    Summary

    Official Symbol
    BOD1provided by HGNC
    Official Full Name
    biorientation of chromosomes in cell division 1provided by HGNC
    Primary source
    HGNC:HGNC:25114
    See related
    Ensembl:ENSG00000145919 MIM:616745; AllianceGenome:HGNC:25114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM44B
    Summary
    Enables protein phosphatase 2A binding activity and protein phosphatase inhibitor activity. Involved in mitotic sister chromatid segregation; negative regulation of phosphoprotein phosphatase activity; and protein localization to chromosome, centromeric region. Located in centrosome; spindle microtubule; and spindle pole. Part of outer kinetochore. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 15.5), ovary (RPKM 14.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BOD1 in Genome Data Viewer
    Location:
    5q35.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (173607145..173616650, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (174147207..174156712, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (173034148..173043653, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172971371-172971870 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:172983296-172984024 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:172995751-172996950 Neighboring gene long intergenic non-protein coding RNA 2995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16639 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:173055264-173056085 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:173059934-173061133 Neighboring gene long intergenic non-protein coding RNA 1863 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:173097006-173097602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23659 Neighboring gene long intergenic non-protein coding RNA 1942

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein phosphatase 2A binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of outer kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    biorientation of chromosomes in cell division protein 1
    Names
    biorientation defective 1
    family with sequence similarity 44, member B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159651.3NP_001153123.1  biorientation of chromosomes in cell division protein 1 isoform b

      See identical proteins and their annotated locations for NP_001153123.1

      Status: VALIDATED

      Source sequence(s)
      AC010339
      Consensus CDS
      CCDS54951.1
      UniProtKB/Swiss-Prot
      Q96IK1
      Related
      ENSP00000285908.5, ENST00000285908.5
      Conserved Domains (1) summary
      pfam05205
      Location:55121
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1
    2. NM_138369.3NP_612378.1  biorientation of chromosomes in cell division protein 1 isoform a

      See identical proteins and their annotated locations for NP_612378.1

      Status: VALIDATED

      Source sequence(s)
      BC007436, BQ881883, DA506589
      Consensus CDS
      CCDS4389.1
      UniProtKB/Swiss-Prot
      B4DXH8, Q96IK1, Q9BTW1
      Related
      ENSP00000309644.4, ENST00000311086.9
      Conserved Domains (1) summary
      pfam05205
      Location:55148
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    RNA

    1. NR_164700.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010339
    2. NR_164701.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010339
    3. NR_164702.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010339
    4. NR_164703.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010339

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      173607145..173616650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      174147207..174156712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)