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    CD1B CD1b molecule [ Homo sapiens (human) ]

    Gene ID: 910, updated on 3-Apr-2024

    Summary

    Official Symbol
    CD1Bprovided by HGNC
    Official Full Name
    CD1b moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1635
    See related
    Ensembl:ENSG00000158485 MIM:188360; AllianceGenome:HGNC:1635
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    R1; CD1; CD1A
    Summary
    This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    1q23.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (158285405..158331531, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (157422502..157468624, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (158297745..158301321, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CD1a molecule Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1899 Neighboring gene CD1c molecule Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1450 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1451 Neighboring gene CD1e molecule Neighboring gene olfactory receptor family 10 subfamily T member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC125990, MGC125991

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables endogenous lipid antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables exogenous lipid antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipopeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antigen processing and presentation, endogenous lipid antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antigen processing and presentation, exogenous lipid antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of T cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in cell surface HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    T-cell surface glycoprotein CD1b
    Names
    CD1B antigen, b polypeptide
    cortical thymocyte antigen CD1B
    differentiation antigen CD1-alpha-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001764.3NP_001755.1  T-cell surface glycoprotein CD1b precursor

      See identical proteins and their annotated locations for NP_001755.1

      Status: REVIEWED

      Source sequence(s)
      AI336342, BC104217, CD687240
      Consensus CDS
      CCDS1176.1
      UniProtKB/Swiss-Prot
      P29016, Q5TDK9, Q5TDL0, Q9UMM2
      UniProtKB/TrEMBL
      B4E0D3
      Related
      ENSP00000357150.3, ENST00000368168.4
      Conserved Domains (2) summary
      cd07698
      Location:203295
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:19198
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      158285405..158331531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002785.3XP_016858274.1  T-cell surface glycoprotein CD1b isoform X3

    2. XM_017002784.3XP_016858273.1  T-cell surface glycoprotein CD1b isoform X2

    3. XM_017002786.3XP_016858275.1  T-cell surface glycoprotein CD1b isoform X4

    4. XM_011510119.4XP_011508421.1  T-cell surface glycoprotein CD1b isoform X1

      See identical proteins and their annotated locations for XP_011508421.1

      UniProtKB/TrEMBL
      H7C0I2
      Related
      ENSP00000395161.1, ENST00000451207.5
      Conserved Domains (2) summary
      cl08246
      Location:19198
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cl11960
      Location:203257
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      157422502..157468624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339537.1XP_054195512.1  T-cell surface glycoprotein CD1b isoform X3

    2. XM_054339538.1XP_054195513.1  T-cell surface glycoprotein CD1b isoform X4

    3. XM_054339536.1XP_054195511.1  T-cell surface glycoprotein CD1b isoform X1