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    ADH4 alcohol dehydrogenase ADH4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852636, updated on 17-May-2024

    Summary

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    Gene symbol
    ADH4
    Gene description
    alcohol dehydrogenase ADH4
    Primary source
    FungiDB:YGL256W
    Locus tag
    YGL256W
    See related
    SGD:S000003225; AllianceGenome:SGD:S000003225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NRC465; ZRG5
    Summary
    Enables alcohol dehydrogenase (NAD+) activity. Involved in amino acid catabolic process to alcohol via Ehrlich pathway and fermentation. Located in mitochondrion. Orthologous to human ADHFE1 (alcohol dehydrogenase iron containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ADH4 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (15159..16307)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Vel1p Neighboring gene alpha-1,3-mannosyltransferase MNT2 Neighboring gene ncRNA Neighboring gene high-affinity Zn(2+) transporter ZRT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Production of Methionol from 3-Methylthiopropionaldehyde by Catalysis of the Yeast Alcohol Dehydrogenase Adh4p. Che Y, et al. J Agric Food Chem, 2020 Apr 22. PMID 32233408
    2. Overexpression, purification and properties of alcohol dehydrogenase IV from Saccharomyces cerevisiae. Drewke C, et al. Biochim Biophys Acta, 1988 May 6. PMID 3282541
    3. Ty insertions at two loci account for most of the spontaneous antimycin A resistance mutations during growth at 15 degrees C of Saccharomyces cerevisiae strains lacking ADH1. Paquin CE, et al. Mol Cell Biol, 1986 Jan. PMID 3023838, Free PMC Article
    4. Resistance to antimycin A in yeast by amplification of ADH4 on a linear, 42 kb palindromic plasmid. Walton JD, et al. Cell, 1986 Sep 12. PMID 3019553
    5. Homology of Saccharomyces cerevisiae ADH4 to an iron-activated alcohol dehydrogenase from Zymomonas mobilis. Williamson VM, et al. Mol Gen Genet, 1987 Sep. PMID 2823079

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables alcohol dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid catabolic process to alcohol via Ehrlich pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in fermentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alcohol dehydrogenase ADH4
    NP_011258.2
    • Alcohol dehydrogenase isoenzyme type IV; dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      15159..16307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181122.1 → NP_011258.2  TPA: alcohol dehydrogenase ADH4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011258.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZTT5, D6VV79, P10127
      UniProtKB/TrEMBL
      A0A8H4C291
      Conserved Domains (1) summary
      cd08188
      Location:5 → 377
      PDDH; 1,3-Propanediol (1,3-PD) dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10127.3

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