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    Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [ Mus musculus (house mouse) ]

    Gene ID: 83409, updated on 23-Jun-2021

    Summary

    Official Symbol
    Lamtor2provided by MGI
    Official Full Name
    late endosomal/lysosomal adaptor, MAPK and MTOR activator 2provided by MGI
    Primary source
    MGI:MGI:1932697
    See related
    Ensembl:ENSMUSG00000028062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ma; P1; P14; Rab; Rob; Rab25; Robld3; Mapbpip; AL022628; 2010111E04Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 88.5), colon adult (RPKM 83.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lamtor2 in Genome Data Viewer
    Location:
    3; 3 F1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88457126..88460258, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88549819..88552951, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (88353741..88356849, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mex3 RNA binding family member A Neighboring gene microRNA 1905 Neighboring gene RAB25, member RAS oncogene family Neighboring gene ubiquilin 4 Neighboring gene RNA transcription, translation and transport factor, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amino acid stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fibroblast migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to cell junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell-substrate junction organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell-substrate junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell-substrate junction organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Ragulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Ragulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ragulator complex protein LAMTOR2
    Names
    endosomal adaptor protein p14
    late endosomal/lysosomal MP1 interacting protein
    late endosomal/lysosomal adaptor and MAPK and MTOR activator 2
    mitogen-activated protein-binding protein-interacting protein
    roadblock domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362368.1NP_001349297.1  ragulator complex protein LAMTOR2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BE629197, BY062676
      Conserved Domains (1) summary
      pfam03259
      Location:877
      Robl_LC7; Roadblock/LC7 domain
    2. NM_031248.4NP_112538.1  ragulator complex protein LAMTOR2 isoform 1

      See identical proteins and their annotated locations for NP_112538.1

      Status: VALIDATED

      Source sequence(s)
      AA250375, BE947263, BY062676
      Consensus CDS
      CCDS17478.1
      UniProtKB/Swiss-Prot
      Q9JHS3
      Related
      ENSMUSP00000029698.9, ENSMUST00000029698.15
      Conserved Domains (1) summary
      pfam03259
      Location:595
      Robl_LC7; Roadblock/LC7 domain

    RNA

    1. NR_155541.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC145168
    2. NR_155542.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC145168
      Related
      ENSMUST00000156421.2
    3. NR_155543.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AW988728, BE947263, BY062676
      Related
      ENSMUST00000119002.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88457126..88460258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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