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    USP5 ubiquitin specific peptidase 5 [ Homo sapiens (human) ]

    Gene ID: 8078, updated on 17-Jun-2024

    Summary

    Official Symbol
    USP5provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 5provided by HGNC
    Primary source
    HGNC:HGNC:12628
    See related
    Ensembl:ENSG00000111667 MIM:601447; AllianceGenome:HGNC:12628
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ISOT
    Summary
    Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]
    Expression
    Ubiquitous expression in testis (RPKM 36.2), brain (RPKM 33.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See USP5 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (6852150..6866632)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (6861449..6875929)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6961314..6975796)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:6937955-6938455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6938503-6939038 Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene G protein subunit beta 3 Neighboring gene cell division cycle associated 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5885 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6960952-6961912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6974948-6975610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6975611-6976272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6979885-6980470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4190 Neighboring gene triosephosphate isomerase 1 Neighboring gene uncharacterized LOC105369632 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6992574-6993122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6993123-6993671 Neighboring gene ribosomal protein L13 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
     
    enables cysteine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in lysosome TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 5
    Names
    deubiquitinating enzyme 5
    isopeptidase T
    testicular tissue protein Li 218
    ubiquitin isopeptidase T
    ubiquitin specific protease 5 (isopeptidase T)
    ubiquitin thioesterase 5
    ubiquitin thiolesterase 5
    ubiquitin-specific protease-5 (ubiquitin isopeptidase T)
    ubiquitin-specific-processing protease 5
    NP_001092006.1
    NP_001369517.1
    NP_001369518.1
    NP_001369519.1
    NP_001369520.1
    NP_003472.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098536.2NP_001092006.1  ubiquitin carboxyl-terminal hydrolase 5 isoform 1

      See identical proteins and their annotated locations for NP_001092006.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC005139, U47927
      Consensus CDS
      CCDS41743.1
      UniProtKB/Swiss-Prot
      D3DUS7, D3DUS8, P45974, Q96J22
      UniProtKB/TrEMBL
      A0A140VJZ1
      Related
      ENSP00000229268.8, ENST00000229268.13
      Conserved Domains (2) summary
      COG5207
      Location:18855
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02658
      Location:327854
      Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    2. NM_001382588.1NP_001369517.1  ubiquitin carboxyl-terminal hydrolase 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      U47924
      Conserved Domains (3) summary
      COG5207
      Location:42813
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02658
      Location:285812
      Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam17807
      Location:1641
      zf-UBP_var; Variant UBP zinc finger
    3. NM_001382589.1NP_001369518.1  ubiquitin carboxyl-terminal hydrolase 5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      U47924
      Conserved Domains (3) summary
      COG5207
      Location:42790
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02658
      Location:285789
      Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam17807
      Location:1641
      zf-UBP_var; Variant UBP zinc finger
    4. NM_001382590.1NP_001369519.1  ubiquitin carboxyl-terminal hydrolase 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      U47924
      Conserved Domains (3) summary
      COG5207
      Location:38786
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02658
      Location:281785
      Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam17807
      Location:133
      zf-UBP_var; Variant UBP zinc finger
    5. NM_001382591.1NP_001369520.1  ubiquitin carboxyl-terminal hydrolase 5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      U47924
      Conserved Domains (1) summary
      COG5207
      Location:18831
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    6. NM_003481.3NP_003472.2  ubiquitin carboxyl-terminal hydrolase 5 isoform 2

      See identical proteins and their annotated locations for NP_003472.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AI289395, BC004889
      Consensus CDS
      CCDS31733.1
      UniProtKB/Swiss-Prot
      P45974
      Related
      ENSP00000373883.5, ENST00000389231.9
      Conserved Domains (2) summary
      COG5207
      Location:18832
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02658
      Location:327831
      Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    RNA

    1. NR_168449.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      U47924
    2. NR_168450.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      U47924
    3. NR_168451.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      U47924
    4. NR_168452.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      U47924
    5. NR_168454.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      U47924
    6. NR_168455.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      U47924
    7. NR_168456.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      U47924
    8. NR_168457.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      U47924
    9. NR_168458.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      U47924

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      6852150..6866632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      6861449..6875929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)