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    Dlst dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) [ Mus musculus (house mouse) ]

    Gene ID: 78920, updated on 2-Oct-2018

    Summary

    Official Symbol
    Dlstprovided by MGI
    Official Full Name
    dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)provided by MGI
    Primary source
    MGI:MGI:1926170
    See related
    Ensembl:ENSMUSG00000004789
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DLTS; 1600017E01Rik; 4632413C10Rik; 4930529O08Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 165.8), kidney adult (RPKM 107.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dlst in Genome Data Viewer
    Location:
    12; 12 D1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (85110821..85134091)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (86451783..86475041)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene YLP motif containing 1 Neighboring gene prospero homeobox 2 opposite strand Neighboring gene prospero homeobox 2 Neighboring gene ribosomal protein S6 kinase-like 1 Neighboring gene placental growth factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    dihydrolipoyllysine-residue succinyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    NADH metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    histone succinylation ISO
    Inferred from Sequence Orthology
    more info
     
    tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    oxoglutarate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
    Names
    2-oxoglutarate dehydrogenase complex component E2
    E2K
    OGDC-E2
    dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex
    NP_084501.1
    XP_006516455.1
    XP_017170736.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030225.4NP_084501.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

      See identical proteins and their annotated locations for NP_084501.1

      Status: VALIDATED

      Source sequence(s)
      AK158877, AK168570, CJ308553
      Consensus CDS
      CCDS26052.1
      UniProtKB/Swiss-Prot
      Q9D2G2
      Related
      ENSMUSP00000060346.8, ENSMUST00000053811.9
      Conserved Domains (3) summary
      cd06849
      Location:72144
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01347
      Location:72454
      sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
      pfam00198
      Location:239452
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      85110821..85134091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516392.3XP_006516455.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1

      Conserved Domains (3) summary
      cd06849
      Location:72144
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01347
      Location:72453
      sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
      pfam00198
      Location:238451
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
    2. XM_017315247.1XP_017170736.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X2

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