Format

Send to:

Choose Destination
    • Showing Current items.

    Appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 72993, updated on 19-Mar-2019

    Summary

    Official Symbol
    Appl1provided by MGI
    Official Full Name
    adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1provided by MGI
    Primary source
    MGI:MGI:1920243
    See related
    Ensembl:ENSMUSG00000040760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DIP13; C88264; AI585782; AW209077; BB022931; 2900057D21Rik; 7330406P05Rik
    Expression
    Broad expression in CNS E18 (RPKM 11.1), whole brain E14.5 (RPKM 9.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See Appl1 in Genome Data Viewer
    Location:
    14; 14 A3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (26918986..26971205, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (27732174..27783737, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 12 Neighboring gene predicted gene, 34415 Neighboring gene ankyrin repeat and SOCS box-containing 14 Neighboring gene host cell factor C1 regulator 1 pseudogene Neighboring gene predicted gene, 41114 Neighboring gene homeobox gene expressed in ES cells Neighboring gene interleukin 17 receptor D

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase B binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adiponectin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hepatocyte growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macropinocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of melanin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of toll-like receptor 4 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    early phagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    macropinosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DCC-interacting protein 13-alpha
    Names
    DIP13 alpha
    adapter protein containing PH domain, PTB domain and leucine zipper motif 1
    adaptor protein APPL like
    dip13-alpha

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145221.2NP_660256.1  DCC-interacting protein 13-alpha

      See identical proteins and their annotated locations for NP_660256.1

      Status: VALIDATED

      Source sequence(s)
      AK033566, AK037695, AK173169, BU514763
      Consensus CDS
      CCDS26883.1
      UniProtKB/Swiss-Prot
      Q8K3H0
      Related
      ENSMUSP00000042875.4, ENSMUST00000036570.4
      Conserved Domains (4) summary
      cd07631
      Location:20234
      BAR_APPL1; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 1
      cd13158
      Location:489624
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:252376
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
      pfam00169
      Location:280375
      PH; PH domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      26918986..26971205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519608.1XP_006519671.1  DCC-interacting protein 13-alpha isoform X1

      Conserved Domains (4) summary
      cd13158
      Location:465600
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:228352
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
      pfam00169
      Location:256351
      PH; PH domain
      cl12013
      Location:20210
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_017316214.1XP_017171703.1  DCC-interacting protein 13-alpha isoform X2

    3. XM_006519609.3XP_006519672.1  DCC-interacting protein 13-alpha isoform X3

      Conserved Domains (4) summary
      cd13158
      Location:312447
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:75199
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
      pfam00169
      Location:103198
      PH; PH domain
      cl12013
      Location:157
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_001781159.1 RNA Sequence

    2. XR_001781158.1 RNA Sequence

    3. XR_001781160.1 RNA Sequence

    Support Center