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    Pcbd2 pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 [ Mus musculus (house mouse) ]

    Gene ID: 72562, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pcbd2provided by MGI
    Official Full Name
    pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2provided by MGI
    Primary source
    MGI:MGI:1919812
    See related
    Ensembl:ENSMUSG00000021496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dcoh; Dcoh2; Dcohm; 2700061N24Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 20.8), bladder adult (RPKM 10.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pcbd2 in Genome Data Viewer
    Location:
    13; 13 B1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55874957..55924643)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55727097..55776830)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55828729..55878191)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA B230219D22 gene Neighboring gene thioredoxin domain containing 15 Neighboring gene RIKEN cDNA 4930451E10 gene Neighboring gene cation channel, sperm associated 3 Neighboring gene paired-like homeodomain transcription factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phenylalanine 4-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    pterin-4-alpha-carbinolamine dehydratase 2
    Names
    4-alpha-hydroxy-tetrahydropterin dehydratase 2
    HNF-1-alpha dimerization cofactor
    PHS 2
    dcoH-like protein DCoHm
    dimerization cofactor of hepatocyte nuclear factor 1 (HNF1) from muscle
    dimerization cofactor of hepatocyte nuclear factor 1 from muscle
    NP_082557.1
    XP_006517461.1
    XP_006517462.1
    XP_006517464.1
    XP_011242866.1
    XP_030103282.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028281.1NP_082557.1  pterin-4-alpha-carbinolamine dehydratase 2

      See identical proteins and their annotated locations for NP_082557.1

      Status: VALIDATED

      Source sequence(s)
      AA013784, BC028642, BY157602
      Consensus CDS
      CCDS26554.1
      UniProtKB/Swiss-Prot
      Q9CZL5
      Related
      ENSMUSP00000021958.6, ENSMUST00000021958.6
      Conserved Domains (1) summary
      cd00914
      Location:57132
      PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      55874957..55924643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517399.4XP_006517462.1  pterin-4-alpha-carbinolamine dehydratase 2 isoform X2

      Conserved Domains (1) summary
      cl00942
      Location:3778
      PCD_DCoH; The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating ...
    2. XM_006517401.5XP_006517464.1  pterin-4-alpha-carbinolamine dehydratase 2 isoform X3

      Conserved Domains (1) summary
      cl00942
      Location:5781
      PCD_DCoH; The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating ...
    3. XM_011244564.3XP_011242866.1  pterin-4-alpha-carbinolamine dehydratase 2 isoform X4

      Conserved Domains (1) summary
      cd00914
      Location:3488
      PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...
    4. XM_006517398.4XP_006517461.1  pterin-4-alpha-carbinolamine dehydratase 2 isoform X1

      Conserved Domains (1) summary
      cd00914
      Location:57162
      PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...
    5. XM_030247422.2XP_030103282.2  pterin-4-alpha-carbinolamine dehydratase 2 isoform X5

      Conserved Domains (1) summary
      cl00942
      Location:150
      PCD_DCoH; The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating ...
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