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    Pigx phosphatidylinositol glycan anchor biosynthesis, class X [ Mus musculus (house mouse) ]

    Gene ID: 72084, updated on 11-Nov-2018

    Summary

    Official Symbol
    Pigxprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Xprovided by MGI
    Primary source
    MGI:MGI:1919334
    See related
    Ensembl:ENSMUSG00000023791 Vega:OTTMUSG00000025806
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PIG-X; 2010319C14Rik
    Summary
    This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 20.4), placenta adult (RPKM 20.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pigx in Genome Data Viewer
    Location:
    16; 16 B2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (32084416..32099727, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (32084502..32099813, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene SUMO/sentrin specific peptidase 5 Neighboring gene high mobility group box 1, pseudogene 6 Neighboring gene p21 (RAC1) activated kinase 2 Neighboring gene centrosomal protein 19 Neighboring gene negative regulator of reactive oxygen species

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol-glycan biosynthesis class X protein
    Names
    phosphatidylinositol glycan, class X

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111025.1NP_001104495.1  phosphatidylinositol-glycan biosynthesis class X protein isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      BX525135, BY708475, CF581933
      Consensus CDS
      CCDS49824.1
      UniProtKB/TrEMBL
      A0A087WSN5
      Related
      ENSMUSP00000141122.1, ENSMUST00000189013.6
      Conserved Domains (1) summary
      pfam08320
      Location:48244
      PIG-X; PIG-X / PBN1
    2. NM_024464.3NP_077784.2  phosphatidylinositol-glycan biosynthesis class X protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_077784.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK008583, BY708475, CF581933
      Consensus CDS
      CCDS28113.2
      UniProtKB/Swiss-Prot
      Q99LV7
      Related
      ENSMUSP00000093819.4, OTTMUSP00000031423, ENSMUST00000096109.10, OTTMUST00000063553
      Conserved Domains (1) summary
      pfam08320
      Location:50246
      PIG-X; PIG-X / PBN1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      32084416..32099727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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