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    Ing3 inhibitor of growth family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 71777, updated on 26-Sep-2022

    Summary

    Official Symbol
    Ing3provided by MGI
    Official Full Name
    inhibitor of growth family, member 3provided by MGI
    Primary source
    MGI:MGI:1919027
    See related
    Ensembl:ENSMUSG00000029670 AllianceGenome:MGI:1919027
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P47ING3; 1300013A07Rik
    Summary
    Predicted to enable methylated histone binding activity. Predicted to be involved in histone acetylation; positive regulation of apoptotic process; and regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization and regulation of growth. Predicted to be located in nucleoplasm. Predicted to be part of Piccolo NuA4 histone acetyltransferase complex and Swr1 complex. Is expressed in several structures, including central nervous system; early conceptus; foregut; genitourinary system; and sensory organ. Orthologous to human ING3 (inhibitor of growth family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 6.3), CNS E11.5 (RPKM 4.1) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ing3 in Genome Data Viewer
    Location:
    6; 6 A3.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (21948002..21976037)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (21949571..21976038)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Shal-related family, member 2 Neighboring gene tetraspanin 12 Neighboring gene predicted gene, 30270 Neighboring gene cadherin-like and PC-esterase domain containing 1 Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene predicted gene 42573

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Piccolo NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Swr1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    inhibitor of growth protein 3
    Names
    p47 regulator protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311061.1NP_001297990.1  inhibitor of growth protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK080787, AK131993, AW457373, BB854183, BX527964, BY705188
      Consensus CDS
      CCDS80491.1
      UniProtKB/Swiss-Prot
      Q8VEK6
      UniProtKB/TrEMBL
      D3YUP8
      Related
      ENSMUSP00000111047.2, ENSMUST00000115389.8
      Conserved Domains (3) summary
      COG5034
      Location:4402
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15585
      Location:354398
      PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
      pfam12998
      Location:3102
      ING; Inhibitor of growth proteins N-terminal histone-binding
    2. NM_023626.4NP_076115.3  inhibitor of growth protein 3 isoform 1

      See identical proteins and their annotated locations for NP_076115.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC117213, AK080787
      Consensus CDS
      CCDS39434.1
      UniProtKB/Swiss-Prot
      Q8VEK6, Q9ERB2
      Related
      ENSMUSP00000031680.4, ENSMUST00000031680.10
      Conserved Domains (3) summary
      COG5034
      Location:4413
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15585
      Location:365409
      PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
      pfam12998
      Location:3102
      ING; Inhibitor of growth proteins N-terminal histone-binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      21948002..21976037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321747.3XP_017177236.1  inhibitor of growth protein 3 isoform X2

      Conserved Domains (3) summary
      COG5034
      Location:235378
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15585
      Location:330374
      PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
      pfam12998
      Location:169
      ING; Inhibitor of growth proteins N-terminal histone-binding
    2. XM_036152310.1XP_036008203.1  inhibitor of growth protein 3 isoform X4

      Conserved Domains (3) summary
      COG5034
      Location:224367
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15585
      Location:319363
      PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
      cd16858
      Location:163
      ING_ING3_Yng2p; Inhibitor of growth (ING) domain of inhibitor of growth protein 3 (ING3), Yng2p and similar proteins
    3. XM_006505166.5XP_006505229.1  inhibitor of growth protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006505229.1

      Conserved Domains (3) summary
      COG5034
      Location:246389
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15585
      Location:341385
      PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
      pfam12998
      Location:380
      ING; Inhibitor of growth proteins N-terminal histone-binding
    4. XM_036152309.1XP_036008202.1  inhibitor of growth protein 3 isoform X3

      Conserved Domains (3) summary
      COG5034
      Location:235378
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15585
      Location:330374
      PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
      cd16858
      Location:874
      ING_ING3_Yng2p; Inhibitor of growth (ING) domain of inhibitor of growth protein 3 (ING3), Yng2p and similar proteins