Ing3 inhibitor of growth family, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ing3provided by MGI
Official Full Name: inhibitor of growth family, member 3provided by MGI
Primary source: MGI:MGI:1919027
See related: Ensembl:ENSMUSG00000029670 AllianceGenome:MGI:1919027
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P47ING3; 1300013A07Rik
Summary: Predicted to enable methylated histone binding activity. Predicted to contribute to histone H2A acetyltransferase activity and histone H4 acetyltransferase activity. Predicted to be involved in positive regulation of double-strand break repair via homologous recombination; regulation of DNA-templated transcription; and regulation of cell cycle. Predicted to be located in nucleoplasm. Predicted to be part of chromatin and piccolo histone acetyltransferase complex. Is expressed in several structures, including central nervous system; early conceptus; foregut; genitourinary system; and sensory organ. Orthologous to human ING3 (inhibitor of growth family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 6.3), CNS E11.5 (RPKM 4.1) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.1; 6 8.81 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (21948002..21976037)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (21949571..21976038)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ING3 levels may serve as a surrogate for growth rate, and suggest possible roles for ING3 in growth and self renewal and related diseases such as cancer.
Title: ING3 protein expression profiling in normal human tissues suggest its role in cellular growth and self-renewal.
ING3 is essential for asymmetric cell division during mouse oocyte maturation
Title: ING3 is essential for asymmetric cell division during mouse oocyte maturation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ING3-1 (e-PCR)
- UniSTS:511816

Ing3 (e-PCR), detects polymorphism
- UniSTS:515968

G20547 (e-PCR)
- UniSTS:47347

A005W09 (e-PCR)
- UniSTS:47348

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H2A acetyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to histone H2A acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromatin organization	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of NuA4 histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Swr1 complex	ISO Inferred from Sequence Orthology more info
part_of Swr1 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of piccolo histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of piccolo histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: inhibitor of growth protein 3

Names: p47 regulator protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311061.1 → NP_001297990.1 inhibitor of growth protein 3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AK080787, AK131993, AW457373, BB854183, BX527964, BY705188

Consensus CDS

CCDS80491.1

UniProtKB/TrEMBL

D3YUP8, Q3V3Y2

Related

ENSMUSP00000111047.2, ENSMUST00000115389.8

Conserved Domains (3) summary

COG5034
Location:4 → 402

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15585
Location:354 → 398

PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins

pfam12998
Location:3 → 102

ING; Inhibitor of growth proteins N-terminal histone-binding
NM_023626.4 → NP_076115.3 inhibitor of growth protein 3 isoform 1

See identical proteins and their annotated locations for NP_076115.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC117213, AK080787

Consensus CDS

CCDS39434.1

UniProtKB/Swiss-Prot

Q8VEK6, Q99JS6, Q9ERB2

UniProtKB/TrEMBL

Q3V3Y2

Related

ENSMUSP00000031680.4, ENSMUST00000031680.10

Conserved Domains (3) summary

COG5034
Location:4 → 413

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15585
Location:365 → 409

PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins

pfam12998
Location:3 → 102

ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

21948002..21976037

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321747.3 → XP_017177236.1 inhibitor of growth protein 3 isoform X2

UniProtKB/TrEMBL

Q3V3Y2

Conserved Domains (3) summary

COG5034
Location:235 → 378

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15585
Location:330 → 374

PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins

pfam12998
Location:1 → 69

ING; Inhibitor of growth proteins N-terminal histone-binding
XM_036152310.1 → XP_036008203.1 inhibitor of growth protein 3 isoform X4

UniProtKB/TrEMBL

Q3V3Y2

Conserved Domains (3) summary

COG5034
Location:224 → 367

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15585
Location:319 → 363

PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins

cd16858
Location:1 → 63

ING_ING3_Yng2p; Inhibitor of growth (ING) domain of inhibitor of growth protein 3 (ING3), Yng2p and similar proteins
XM_006505166.5 → XP_006505229.1 inhibitor of growth protein 3 isoform X1

See identical proteins and their annotated locations for XP_006505229.1

UniProtKB/TrEMBL

Q3V3Y2

Conserved Domains (3) summary

COG5034
Location:246 → 389

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15585
Location:341 → 385

PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins

pfam12998
Location:3 → 80

ING; Inhibitor of growth proteins N-terminal histone-binding
XM_036152309.1 → XP_036008202.1 inhibitor of growth protein 3 isoform X3

UniProtKB/TrEMBL

Q3V3Y2

Conserved Domains (3) summary

COG5034
Location:235 → 378

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15585
Location:330 → 374

PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins

cd16858
Location:8 → 74

ING_ING3_Yng2p; Inhibitor of growth (ING) domain of inhibitor of growth protein 3 (ING3), Yng2p and similar proteins