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    Arhgap42 Rho GTPase activating protein 42 [ Mus musculus (house mouse) ]

    Gene ID: 71544, updated on 31-Jan-2019

    Summary

    Official Symbol
    Arhgap42provided by MGI
    Official Full Name
    Rho GTPase activating protein 42provided by MGI
    Primary source
    MGI:MGI:1918794
    See related
    Ensembl:ENSMUSG00000050730
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BE136619; 9030420J04Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.1), limb E14.5 (RPKM 6.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See Arhgap42 in Genome Data Viewer
    Location:
    9; 9 A1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (8994332..9239166, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (8994953..9239013, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 6 Neighboring gene predicted gene, 32014 Neighboring gene progesterone receptor Neighboring gene predicted gene, 16833 Neighboring gene predicted gene, 46102 Neighboring gene contactin 5 Neighboring gene microRNA 6237

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of systemic arterial blood pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of vascular smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 42
    Names
    VRho GTPase activating protein 42
    arhgap42

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027823.1NP_082099.1  rho GTPase-activating protein 42

      See identical proteins and their annotated locations for NP_082099.1

      Status: PROVISIONAL

      Source sequence(s)
      BC137892
      Consensus CDS
      CCDS52720.1
      UniProtKB/Swiss-Prot
      B2RQE8
      Related
      ENSMUSP00000091419.4, ENSMUST00000093893.11
      Conserved Domains (5) summary
      cd12066
      Location:787841
      SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
      cd01249
      Location:233342
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:233335
      PH; PH domain
      cl02570
      Location:335533
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:19191
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      8994332..9239166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509884.3XP_006509947.1  rho GTPase-activating protein 42 isoform X1

      Conserved Domains (5) summary
      cd07634
      Location:19225
      BAR_GAP10-like; The Bin/Amphiphysin/Rvs (BAR) domain of Rho GTPase activating protein 10-like
      cd12066
      Location:821875
      SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
      cd01249
      Location:267376
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:267369
      PH; PH domain
      cl02570
      Location:369567
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
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