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    Polr3b polymerase (RNA) III (DNA directed) polypeptide B [ Mus musculus (house mouse) ]

    Gene ID: 70428, updated on 23-Jun-2021

    Summary

    Official Symbol
    Polr3bprovided by MGI
    Official Full Name
    polymerase (RNA) III (DNA directed) polypeptide Bprovided by MGI
    Primary source
    MGI:MGI:1917678
    See related
    Ensembl:ENSMUSG00000034453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RP; C128; RPC2; C85372; 2700078H01Rik; A330032P03Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.5), CNS E14 (RPKM 4.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Polr3b in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (84458156..84563042)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (84622292..84727178)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (84085182..84189923)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene t-complex 11 (mouse) like 2 Neighboring gene predicted gene, 25657 Neighboring gene predicted gene, 17249 Neighboring gene regulatory factor X, 4 (influences HLA class II expression) Neighboring gene predicted gene, 53596 Neighboring gene predicted gene, 40728

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA-directed 5'-3' RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribonucleoside binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerase III subunit RPC2
    Names
    DNA-directed RNA polymerase III 127.6 kDa polypeptide
    DNA-directed RNA polymerase III subunit B
    RNA polymerase III subunit C2
    RNA polymerase III subunit RPC2 homolog
    NP_081699.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027423.2NP_081699.1  DNA-directed RNA polymerase III subunit RPC2

      See identical proteins and their annotated locations for NP_081699.1

      Status: VALIDATED

      Source sequence(s)
      AK165886, BC068143
      Consensus CDS
      CCDS24081.1
      UniProtKB/Swiss-Prot
      P59470
      Related
      ENSMUSP00000076418.6, ENSMUST00000077175.7
      Conserved Domains (4) summary
      PRK08565
      Location:261129
      PRK08565; DNA-directed RNA polymerase subunit B; Provisional
      cd00653
      Location:391127
      RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
      pfam04566
      Location:539600
      RNA_pol_Rpb2_4; RNA polymerase Rpb2, domain 4
      pfam04567
      Location:621661
      RNA_pol_Rpb2_5; RNA polymerase Rpb2, domain 5

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      84458156..84563042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_380439.5 RNA Sequence

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