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    Tmem30a transmembrane protein 30A [ Mus musculus (house mouse) ]

    Gene ID: 69981, updated on 26-Sep-2022

    Summary

    Official Symbol
    Tmem30aprovided by MGI
    Official Full Name
    transmembrane protein 30Aprovided by MGI
    Primary source
    MGI:MGI:106402
    See related
    Ensembl:ENSMUSG00000032328 AllianceGenome:MGI:106402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdc50a; D9Wsu20e; 2010200I23Rik
    Summary
    Predicted to enable aminophospholipid flippase activity. Involved in positive regulation of neuron projection development. Acts upstream of or within phospholipid translocation. Predicted to be located in cytoplasmic vesicle and membrane. Predicted to be integral component of membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and plasma membrane. Is expressed in extraembryonic component. Orthologous to human TMEM30A (transmembrane protein 30A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 34.3), cerebellum adult (RPKM 30.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Tmem30a in Genome Data Viewer
    Location:
    9 E1; 9 43.82 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (79676223..79700712, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (79768941..79793430, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene collagen, type XII, alpha 1 Neighboring gene predicted gene, 51685 Neighboring gene RIKEN cDNA 4930429F24 gene Neighboring gene cytochrome c oxidase subunit 7A2 Neighboring gene filamin A interacting protein 1 Neighboring gene predicted gene, 35261

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminophospholipid flippase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cell cycle control protein 50A
    Names
    P4-ATPase flippase complex beta subunit TMEM30A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133718.4NP_598479.1  cell cycle control protein 50A

      See identical proteins and their annotated locations for NP_598479.1

      Status: VALIDATED

      Source sequence(s)
      AK077065, AK159364, BY470970
      Consensus CDS
      CCDS23367.1
      UniProtKB/Swiss-Prot
      Q8VEH1, Q8VEK0
      Related
      ENSMUSP00000034878.6, ENSMUST00000034878.12
      Conserved Domains (1) summary
      pfam03381
      Location:75353
      CDC50; LEM3 (ligand-effect modulator 3) family / CDC50 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      79676223..79700712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)