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    Mul1 mitochondrial ubiquitin ligase activator of NFKB 1 [ Mus musculus (house mouse) ]

    Gene ID: 68350, updated on 5-Aug-2018

    Summary

    Official Symbol
    Mul1provided by MGI
    Official Full Name
    mitochondrial ubiquitin ligase activator of NFKB 1provided by MGI
    Primary source
    MGI:MGI:1915600
    See related
    Ensembl:ENSMUSG00000041241 Vega:OTTMUSG00000010003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gide; AV000801; 0610009K11Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 21.6), colon adult (RPKM 15.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mul1 in Genome Data Viewer
    Location:
    4; 4 D3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (138434659..138442265)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (137990587..137998180)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 43, member B Neighboring gene ribosomal protein L38, pseudogene 1 Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 1 Neighboring gene predicted gene, 32549

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion localization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of chemokine (C-C motif) ligand 5 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    organelle organization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendrite extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrial membrane potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial ubiquitin ligase activator of NFKB 1
    Names
    E3 ubiquitin ligase
    E3 ubiquitin-protein ligase MUL1
    RING-type E3 ubiquitin transferase NFKB 1
    growth inhibition and death E3 ligase
    NP_080965.2
    XP_006539197.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026689.3NP_080965.2  mitochondrial ubiquitin ligase activator of NFKB 1

      See identical proteins and their annotated locations for NP_080965.2

      Status: VALIDATED

      Source sequence(s)
      AK076419, AK083295, BB856128, BY062056
      Consensus CDS
      CCDS18828.1
      UniProtKB/Swiss-Prot
      Q8VCM5
      Related
      ENSMUSP00000039604.4, OTTMUSP00000010634, ENSMUST00000044058.10, OTTMUST00000023264
      Conserved Domains (2) summary
      pfam12483
      Location:97251
      GIDE; E3 Ubiquitin ligase
      pfam13920
      Location:302346
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      138434659..138442265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539134.3XP_006539197.1  mitochondrial ubiquitin ligase activator of NFKB 1 isoform X1

      See identical proteins and their annotated locations for XP_006539197.1

      UniProtKB/Swiss-Prot
      Q8VCM5
      Related
      ENSMUSP00000101439.1, OTTMUSP00000010635, ENSMUST00000105813.7, OTTMUST00000023265
      Conserved Domains (2) summary
      pfam12483
      Location:92246
      GIDE; E3 Ubiquitin ligase
      pfam13920
      Location:297341
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
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