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    Cert1 ceramide transporter 1 [ Mus musculus (house mouse) ]

    Gene ID: 68018, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cert1provided by MGI
    Official Full Name
    ceramide transporter 1provided by MGI
    Primary source
    MGI:MGI:1915268
    See related
    Ensembl:ENSMUSG00000021669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GP; Cer; CERT; Col4; GPBP; AU016711; Col4a3bp; 2810404O15Rik; 9230101K08Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 14.2), adrenal adult (RPKM 13.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cert1 in Genome Data Viewer
    Location:
    13; 13 D1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (96679243..96782362)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (96542709..96640167)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (97312690..97410122)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene POC5 centriolar protein Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene polymerase (DNA directed), kappa Neighboring gene predicted gene, 46436 Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Neighboring gene predicted gene, 33171

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ceramide 1-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ceramide 1-phosphate transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ceramide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ceramide transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ER to Golgi ceramide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ER to Golgi ceramide transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ER to Golgi ceramide transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ceramide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ceramide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intermembrane lipid transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intermembrane sphingolipid transfer ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mitochondrion morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ceramide transfer protein
    Names
    START domain-containing protein 11
    ceramide transport protein
    collagen type IV alpha-3-binding protein
    collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
    goodpasture antigen-binding protein
    procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein
    stAR-related lipid transfer protein 11
    stARD11
    NP_001157694.1
    NP_075909.1
    XP_030103245.1
    XP_036014034.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164222.1NP_001157694.1  ceramide transfer protein isoform 2

      See identical proteins and their annotated locations for NP_001157694.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC122828, AC154851, AK012989, BB654693
      Consensus CDS
      CCDS49335.1
      UniProtKB/Swiss-Prot
      Q9EQG9
      Related
      ENSMUSP00000105070.3, ENSMUST00000109444.3
      Conserved Domains (2) summary
      cd08872
      Location:364598
      START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains
      cd13283
      Location:26125
      PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain
    2. NM_023420.2NP_075909.1  ceramide transfer protein isoform 1

      See identical proteins and their annotated locations for NP_075909.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122828, AC154851, AK012989, AK080958, BB654693
      Consensus CDS
      CCDS26705.1
      UniProtKB/Swiss-Prot
      Q9EQG9
      Related
      ENSMUSP00000076856.5, ENSMUST00000077672.12
      Conserved Domains (2) summary
      cd08872
      Location:391624
      START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains
      cd13283
      Location:26125
      PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      96679243..96782362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247385.2XP_030103245.1  ceramide transfer protein isoform X1

      Conserved Domains (1) summary
      cd08872
      Location:259492
      START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains
    2. XM_036158141.1XP_036014034.1  ceramide transfer protein isoform X2

      Conserved Domains (2) summary
      cd13283
      Location:26125
      PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain
      cl14643
      Location:364557
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
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