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    Atg12 autophagy related 12 [ Mus musculus (house mouse) ]

    Gene ID: 67526, updated on 31-Jan-2019

    Summary

    Official Symbol
    Atg12provided by MGI
    Official Full Name
    autophagy related 12provided by MGI
    Primary source
    MGI:MGI:1914776
    See related
    Ensembl:ENSMUSG00000032905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apg12l; Atg12l; 4931423H11Rik; A330058M13Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 28.2), placenta adult (RPKM 26.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Atg12 in Genome Data Viewer
    Location:
    18; 18 C
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (46732417..46741839, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (46892071..46901233, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene 3734 Neighboring gene cysteine dioxygenase 1, cytosolic Neighboring gene adaptor-related protein complex 3, sigma 1 subunit Neighboring gene laeverin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Atg8 ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    C-terminal protein lipidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    autophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Atg12-Atg5-Atg16 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phagophore assembly site membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin-like protein ATG12
    Names
    autophagy-related protein 12

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026217.3NP_080493.2  ubiquitin-like protein ATG12

      See identical proteins and their annotated locations for NP_080493.2

      Status: VALIDATED

      Source sequence(s)
      AV295996, BB853539, BC070470
      Consensus CDS
      CCDS37811.1
      UniProtKB/Swiss-Prot
      Q9CQY1
      Related
      ENSMUSP00000038489.4, ENSMUST00000035648.5
      Conserved Domains (1) summary
      pfam04110
      Location:55141
      APG12; Ubiquitin-like autophagy protein Apg12

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      46732417..46741839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526187.1XP_006526250.1  ubiquitin-like protein ATG12 isoform X1

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