Format

Send to:

Choose Destination
    • Showing Current items.

    Dram2 DNA-damage regulated autophagy modulator 2 [ Mus musculus (house mouse) ]

    Gene ID: 67171, updated on 28-Aug-2018

    Summary

    Official Symbol
    Dram2provided by MGI
    Official Full Name
    DNA-damage regulated autophagy modulator 2provided by MGI
    Primary source
    MGI:MGI:1914421
    See related
    Ensembl:ENSMUSG00000027900 Vega:OTTMUSG00000029479
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem77; AI647667; 2010305N14Rik; 2610318G18Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 19.9), kidney adult (RPKM 15.2) and 27 other tissues See more
    Orthologs

    Genomic context

    See Dram2 in Genome Data Viewer
    Location:
    3; 3 F2.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (106547798..106575341)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (106350745..106377763)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene chitinase-like 6 Neighboring gene RIKEN cDNA 2010016I18 gene Neighboring gene DENN/MADD domain containing 2D Neighboring gene choline/ethanolaminephosphotransferase 1 Neighboring gene ligand dependent nuclear receptor interacting factor 1 Neighboring gene CD53 antigen

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    photoreceptor cell maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    photoreceptor cell maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    visual perception ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA damage-regulated autophagy modulator protein 2
    Names
    VDNA-damage regulated autophagy modulator 2
    transmembrane protein 77

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025582.2NP_001020753.1  DNA damage-regulated autophagy modulator protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001020753.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks two alternate in-frame exons in the 3' coding region compared to variant 2. It encodes isoform 1 which is shorter than isoform 2.
      Source sequence(s)
      AC117200, AI875295, AK008532
      Consensus CDS
      CCDS17724.1
      UniProtKB/TrEMBL
      Q9D835
      Related
      ENSMUSP00000029507.6, OTTMUSP00000037762, ENSMUST00000029507.12, OTTMUST00000073044
      Conserved Domains (1) summary
      pfam10277
      Location:7113
      Frag1; Frag1/DRAM/Sfk1 family
    2. NM_001286986.1NP_001273915.1  DNA damage-regulated autophagy modulator protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001273915.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 2, 3 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AC117200, AI875295, AK015888
      Consensus CDS
      CCDS17725.1
      UniProtKB/Swiss-Prot
      Q9CR48
      Conserved Domains (1) summary
      pfam10277
      Location:7233
      Frag1; Frag1/DRAM/Sfk1 family
    3. NM_001286987.1NP_001273916.1  DNA damage-regulated autophagy modulator protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001273916.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Variants 2, 3 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AC117200, AI875295, AK052824
      Consensus CDS
      CCDS17725.1
      UniProtKB/Swiss-Prot
      Q9CR48
      Related
      ENSMUSP00000112680.1, OTTMUSP00000037761, ENSMUST00000121034.7, OTTMUST00000073043
      Conserved Domains (1) summary
      pfam10277
      Location:7233
      Frag1; Frag1/DRAM/Sfk1 family
    4. NM_026013.3NP_080289.1  DNA damage-regulated autophagy modulator protein 2 isoform 2

      See identical proteins and their annotated locations for NP_080289.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (2). Variants 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC117200, AI875295, AK009940
      Consensus CDS
      CCDS17725.1
      UniProtKB/Swiss-Prot
      Q9CR48
      Related
      ENSMUSP00000063510.6, OTTMUSP00000037760, ENSMUST00000067630.12, OTTMUST00000073042
      Conserved Domains (1) summary
      pfam10277
      Location:7233
      Frag1; Frag1/DRAM/Sfk1 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      106547798..106575341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501928.1XP_006501991.1  DNA damage-regulated autophagy modulator protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006501991.1

      Conserved Domains (1) summary
      pfam10277
      Location:1175
      Frag1; Frag1/DRAM/Sfk1 family
    2. XM_006501929.3XP_006501992.1  DNA damage-regulated autophagy modulator protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006501992.1

      UniProtKB/TrEMBL
      Q9D835
      Conserved Domains (1) summary
      pfam10277
      Location:7113
      Frag1; Frag1/DRAM/Sfk1 family
    Support Center