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    Dram2 DNA-damage regulated autophagy modulator 2 [ Mus musculus (house mouse) ]

    Gene ID: 67171, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dram2provided by MGI
    Official Full Name
    DNA-damage regulated autophagy modulator 2provided by MGI
    Primary source
    MGI:MGI:1914421
    See related
    Ensembl:ENSMUSG00000027900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem77; AI647667; 2010305N14Rik; 2610318G18Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 19.9), kidney adult (RPKM 15.2) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Dram2 in Genome Data Viewer
    Location:
    3; 3 F2.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106455114..106482657)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (106547798..106575341)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (106350745..106377763)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene chitinase-like 6 Neighboring gene RIKEN cDNA 2010016I18 gene Neighboring gene DENN/MADD domain containing 2D Neighboring gene choline/ethanolaminephosphotransferase 1 Neighboring gene ligand dependent nuclear receptor interacting factor 1 Neighboring gene CD53 antigen

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in photoreceptor cell maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in photoreceptor cell maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in photoreceptor cell maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA damage-regulated autophagy modulator protein 2
    Names
    VDNA-damage regulated autophagy modulator 2
    transmembrane protein 77

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025582.2NP_001020753.1  DNA damage-regulated autophagy modulator protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001020753.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks two alternate in-frame exons in the 3' coding region compared to variant 2. It encodes isoform 1 which is shorter than isoform 2.
      Source sequence(s)
      AC117200, AI875295, AK008532
      Consensus CDS
      CCDS17724.1
      UniProtKB/TrEMBL
      Q9D835
      Related
      ENSMUSP00000029507.7, ENSMUST00000029507.13
      Conserved Domains (1) summary
      pfam10277
      Location:7113
      Frag1; Frag1/DRAM/Sfk1 family
    2. NM_001286986.1NP_001273915.1  DNA damage-regulated autophagy modulator protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001273915.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 2, 3 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AC117200, AI875295, AK015888
      Consensus CDS
      CCDS17725.1
      UniProtKB/Swiss-Prot
      Q9CR48
      Conserved Domains (1) summary
      pfam10277
      Location:7233
      Frag1; Frag1/DRAM/Sfk1 family
    3. NM_001286987.1NP_001273916.1  DNA damage-regulated autophagy modulator protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001273916.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Variants 2, 3 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AC117200, AI875295, AK052824
      Consensus CDS
      CCDS17725.1
      UniProtKB/Swiss-Prot
      Q9CR48
      Related
      ENSMUSP00000112680.2, ENSMUST00000121034.8
      Conserved Domains (1) summary
      pfam10277
      Location:7233
      Frag1; Frag1/DRAM/Sfk1 family
    4. NM_026013.3NP_080289.1  DNA damage-regulated autophagy modulator protein 2 isoform 2

      See identical proteins and their annotated locations for NP_080289.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (2). Variants 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC117200, AI875295, AK009940
      Consensus CDS
      CCDS17725.1
      UniProtKB/Swiss-Prot
      Q9CR48
      Related
      ENSMUSP00000063510.7, ENSMUST00000067630.13
      Conserved Domains (1) summary
      pfam10277
      Location:7233
      Frag1; Frag1/DRAM/Sfk1 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      106455114..106482657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163241.1XP_036019134.1  DNA damage-regulated autophagy modulator protein 2 isoform X1

      Conserved Domains (1) summary
      pfam10277
      Location:7233
      Frag1; Frag1/DRAM/Sfk1 family
    2. XM_006501929.5XP_006501992.1  DNA damage-regulated autophagy modulator protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006501992.1

      UniProtKB/TrEMBL
      Q9D835
      Conserved Domains (1) summary
      pfam10277
      Location:7113
      Frag1; Frag1/DRAM/Sfk1 family
    3. XM_006501928.1XP_006501991.1  DNA damage-regulated autophagy modulator protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006501991.1

      Conserved Domains (1) summary
      pfam10277
      Location:1175
      Frag1; Frag1/DRAM/Sfk1 family
    4. XM_036163242.1XP_036019135.1  DNA damage-regulated autophagy modulator protein 2 isoform X1

      Conserved Domains (1) summary
      pfam10277
      Location:7233
      Frag1; Frag1/DRAM/Sfk1 family
    5. XM_030252770.2XP_030108630.1  DNA damage-regulated autophagy modulator protein 2 isoform X3

      Conserved Domains (1) summary
      pfam10277
      Location:7113
      Frag1; Frag1/DRAM/Sfk1 family
    6. XM_036163243.1XP_036019136.1  DNA damage-regulated autophagy modulator protein 2 isoform X1

      Conserved Domains (1) summary
      pfam10277
      Location:7233
      Frag1; Frag1/DRAM/Sfk1 family
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