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    Crls1 cardiolipin synthase 1 [ Mus musculus (house mouse) ]

    Gene ID: 66586, updated on 31-Jan-2019

    Summary

    Official Symbol
    Crls1provided by MGI
    Official Full Name
    cardiolipin synthase 1provided by MGI
    Primary source
    MGI:MGI:1913836
    See related
    Ensembl:ENSMUSG00000027357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610009I22Rik; 4930557M15Rik; 5730490M08Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 28.2), adrenal adult (RPKM 25.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Crls1 in Genome Data Viewer
    Location:
    2; 2 F2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (132846652..132866786)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (132672402..132692509)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 6 Neighboring gene minichromosome maintenance 8 homologous recombination repair factor Neighboring gene leucine rich repeat neuronal 4 Neighboring gene fermitin family member 1 Neighboring gene predicted gene 14102 Neighboring gene formin binding protein 4 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cardiolipin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cardiolipin synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cardiolipin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycerophospholipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    response to phosphatidylethanolamine ISO
    Inferred from Sequence Orthology
    more info
     
    response to thyroxine ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    cardiolipin synthase (CMP-forming)
    Names
    CLS
    NP_001019556.1
    NP_079922.2
    XP_006500075.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024385.1NP_001019556.1  cardiolipin synthase (CMP-forming) isoform 1

      See identical proteins and their annotated locations for NP_001019556.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK018180, BC048702, BC086619
      Consensus CDS
      CCDS16779.1
      UniProtKB/Swiss-Prot
      Q80ZM8
      Related
      ENSMUSP00000028835.6, ENSMUST00000028835.12
      Conserved Domains (1) summary
      COG0558
      Location:108298
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]
    2. NM_025646.3NP_079922.2  cardiolipin synthase (CMP-forming) isoform 2

      See identical proteins and their annotated locations for NP_079922.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon and the translation initiates from a downstream AUG codon, as compared to variant 1. The encoded isoform 2 has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK016165, BC086619
      Consensus CDS
      CCDS38247.1
      UniProtKB/Swiss-Prot
      Q80ZM8
      UniProtKB/TrEMBL
      A0A0C3SFZ5
      Related
      ENSMUSP00000132682.1, ENSMUST00000124836.7
      Conserved Domains (1) summary
      COG0558
      Location:1183
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      132846652..132866786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500012.2XP_006500075.1  cardiolipin synthase (CMP-forming) isoform X1

      See identical proteins and their annotated locations for XP_006500075.1

      Related
      ENSMUSP00000129137.1, ENSMUST00000154160.1
      Conserved Domains (1) summary
      COG0558
      Location:8198
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

    RNA

    1. XR_866333.2 RNA Sequence

      Related
      ENSMUST00000124834.7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024384.1: Suppressed sequence

      Description
      NM_001024384.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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