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    Crls1 cardiolipin synthase 1 [ Mus musculus (house mouse) ]

    Gene ID: 66586, updated on 29-Jun-2021

    Summary

    Official Symbol
    Crls1provided by MGI
    Official Full Name
    cardiolipin synthase 1provided by MGI
    Primary source
    MGI:MGI:1913836
    See related
    Ensembl:ENSMUSG00000027357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610009I22Rik; 4930557M15Rik; 5730490M08Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 28.2), adrenal adult (RPKM 25.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Crls1 in Genome Data Viewer
    Location:
    2; 2 F2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132688557..132708706)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132846650..132866786)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (132672402..132692509)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene chromogranin B Neighboring gene tRNA methyltransferase 6 Neighboring gene minichromosome maintenance 8 homologous recombination repair factor Neighboring gene leucine rich repeat neuronal 4 Neighboring gene predicted gene, 54154 Neighboring gene fermitin family member 1 Neighboring gene predicted gene 14102

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cardiolipin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cardiolipin synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cardiolipin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glycerophospholipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to phosphatidylethanolamine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to thyroxine ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    cardiolipin synthase (CMP-forming)
    Names
    CLS
    NP_001019556.1
    NP_079922.2
    XP_006500075.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024385.1NP_001019556.1  cardiolipin synthase (CMP-forming) isoform 1

      See identical proteins and their annotated locations for NP_001019556.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK018180, BC048702, BC086619
      Consensus CDS
      CCDS16779.1
      UniProtKB/Swiss-Prot
      Q80ZM8
      Related
      ENSMUSP00000028835.7, ENSMUST00000028835.13
      Conserved Domains (1) summary
      COG0558
      Location:108298
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]
    2. NM_025646.3NP_079922.2  cardiolipin synthase (CMP-forming) isoform 2

      See identical proteins and their annotated locations for NP_079922.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon and the translation initiates from a downstream AUG codon, as compared to variant 1. The encoded isoform 2 has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK016165, BC086619
      Consensus CDS
      CCDS38247.1
      UniProtKB/Swiss-Prot
      Q80ZM8
      UniProtKB/TrEMBL
      A0A0C3SFZ5
      Related
      ENSMUSP00000132682.2, ENSMUST00000124836.8
      Conserved Domains (1) summary
      PLN02794
      Location:1174
      PLN02794; cardiolipin synthase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      132688557..132708706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500012.3XP_006500075.1  cardiolipin synthase (CMP-forming) isoform X1

      See identical proteins and their annotated locations for XP_006500075.1

      Related
      ENSMUSP00000129137.2, ENSMUST00000154160.2
      Conserved Domains (1) summary
      PLN02794
      Location:10189
      PLN02794; cardiolipin synthase

    RNA

    1. XR_866333.4 RNA Sequence

      Related
      ENSMUST00000124834.8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024384.1: Suppressed sequence

      Description
      NM_001024384.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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