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    Polr2e polymerase (RNA) II (DNA directed) polypeptide E [ Mus musculus (house mouse) ]

    Gene ID: 66420, updated on 26-Sep-2022

    Summary

    Official Symbol
    Polr2eprovided by MGI
    Official Full Name
    polymerase (RNA) II (DNA directed) polypeptide Eprovided by MGI
    Primary source
    MGI:MGI:1913670
    See related
    Ensembl:ENSMUSG00000004667 AllianceGenome:MGI:1913670
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPB5; XAP4; 25kDa; 2410021N14Rik
    Summary
    Predicted to enable DNA binding activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Is expressed in several structures, including branchial arch; limb; maxillary process; nervous system; and sensory organ. Orthologous to human POLR2E (RNA polymerase II, I and III subunit E). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 144.4), placenta adult (RPKM 108.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Polr2e in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79871787..79875493, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80035953..80039659, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 7 Neighboring gene Rho GTPase activating protein 45 Neighboring gene glutathione peroxidase 4 Neighboring gene strawberry notch 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA-directed 5'-3' RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RPAP3/R2TP/prefoldin-like complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerases I, II, and III subunit RPABC1
    Names
    DNA-directed RNA polymerase II subunit E
    RNA polymerases I, II, and III subunit ABC1
    RPB5 homolog
    NP_079830.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025554.2NP_079830.2  DNA-directed RNA polymerases I, II, and III subunit RPABC1

      See identical proteins and their annotated locations for NP_079830.2

      Status: PROVISIONAL

      Source sequence(s)
      BC045521
      Consensus CDS
      CCDS35972.1
      UniProtKB/Swiss-Prot
      Q80UW8
      UniProtKB/TrEMBL
      A0A6P5QIT7, A0A8C6GEP6, Q3V214
      Related
      ENSMUSP00000004786.10, ENSMUST00000004786.10
      Conserved Domains (1) summary
      PLN03111
      Location:1209
      PLN03111; DNA-directed RNA polymerase II subunit family protein; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79871787..79875493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)