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    LGALS9C galectin 9C [ Homo sapiens (human) ]

    Gene ID: 654346, updated on 6-Jun-2024

    Summary

    Official Symbol
    LGALS9Cprovided by HGNC
    Official Full Name
    galectin 9Cprovided by HGNC
    Primary source
    HGNC:HGNC:33874
    See related
    Ensembl:ENSG00000171916 AllianceGenome:HGNC:33874
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Gal-9B; LGALS9B
    Summary
    This gene was initially thought to represent a pseudogene of galectin 9; however, this transcript has good exon-intron structure and encodes a predicted protein of the same size as and highly similar to galectin 9. This gene is one of two similar loci on chromosome 17p similar to galectin 9 and now thought to be protein-encoding. This gene is the more telomeric gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in stomach (RPKM 22.9), gall bladder (RPKM 8.6) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LGALS9C in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (18476789..18494945)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (18423619..18441775)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (18380103..18398259)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 16 pseudogene 4 Neighboring gene transportin 1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18400380-18400880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18400881-18401381 Neighboring gene nitric oxide synthase 2 pseudogene 2 Neighboring gene ubiquitin specific peptidase 32 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC125972

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables galactoside binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of type II interferon production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    galectin-9C
    Names
    Galectin-9-like protein A
    Galectin-9B
    gal-9C
    galectin 9 like
    galectin-9-like protein B
    lectin, galactoside-binding, soluble, 9 (galectin 9) pseudogene
    lectin, galactoside-binding, soluble, 9C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040078.3NP_001035167.2  galectin-9C

      See identical proteins and their annotated locations for NP_001035167.2

      Status: VALIDATED

      Source sequence(s)
      BC073889, BM769737, DA426549
      Consensus CDS
      CCDS32587.1
      UniProtKB/Swiss-Prot
      B0AZM7, Q6DKI2
      UniProtKB/TrEMBL
      B3KWW5
      Related
      ENSP00000329932.6, ENST00000328114.11
      Conserved Domains (2) summary
      smart00908
      Location:233355
      Gal-bind_lectin; Galactoside-binding lectin
      cd00070
      Location:16146
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      18476789..18494945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011523995.2XP_011522297.1  galectin-9C isoform X5

      UniProtKB/TrEMBL
      J3QR96
      Conserved Domains (2) summary
      cd00070
      Location:16146
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
      cl00071
      Location:227254
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
    2. XM_005256769.2XP_005256826.1  galectin-9C isoform X1

      UniProtKB/TrEMBL
      B3KWW5
      Conserved Domains (2) summary
      smart00908
      Location:232354
      Gal-bind_lectin; Galactoside-binding lectin
      cd00070
      Location:16146
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
    3. XM_011523993.2XP_011522295.1  galectin-9C isoform X2

      UniProtKB/TrEMBL
      B3KWW5
      Conserved Domains (2) summary
      smart00908
      Location:201323
      Gal-bind_lectin; Galactoside-binding lectin
      cd00070
      Location:16146
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
    4. XM_005256770.2XP_005256827.1  galectin-9C isoform X3

      UniProtKB/TrEMBL
      B3KWW5, J3KSY2
      Related
      ENSP00000462708.1, ENST00000583322.5
      Conserved Domains (2) summary
      smart00908
      Location:200322
      Gal-bind_lectin; Galactoside-binding lectin
      cd00070
      Location:16146
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
    5. XM_024450891.2XP_024306659.1  galectin-9C isoform X8

      UniProtKB/TrEMBL
      J3QR96
      Related
      ENSP00000464108.1, ENST00000581545.5
      Conserved Domains (2) summary
      cd00070
      Location:16146
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
      cl00071
      Location:194221
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
    6. XM_011523994.2XP_011522296.1  galectin-9C isoform X4

      UniProtKB/TrEMBL
      B3KWW5
      Conserved Domains (2) summary
      smart00908
      Location:189311
      Gal-bind_lectin; Galactoside-binding lectin
      cd00070
      Location:16146
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
    7. XM_011523996.1XP_011522298.1  galectin-9C isoform X6

      UniProtKB/TrEMBL
      B4DKP4
      Conserved Domains (1) summary
      smart00908
      Location:145267
      Gal-bind_lectin; Galactoside-binding lectin
    8. XM_011523997.1XP_011522299.1  galectin-9C isoform X7

      UniProtKB/TrEMBL
      B4DKP4
      Conserved Domains (2) summary
      smart00908
      Location:130252
      Gal-bind_lectin; Galactoside-binding lectin
      cl00071
      Location:843
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_017363819.1 Reference GRCh38.p14 PATCHES

      Range
      246768..264924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332109.1XP_054188084.1  galectin-9C isoform X5

      UniProtKB/TrEMBL
      J3QR96
    2. XM_054332105.1XP_054188080.1  galectin-9C isoform X1

      UniProtKB/TrEMBL
      B3KWW5
    3. XM_054332106.1XP_054188081.1  galectin-9C isoform X2

      UniProtKB/TrEMBL
      B3KWW5
    4. XM_054332107.1XP_054188082.1  galectin-9C isoform X3

      UniProtKB/TrEMBL
      B3KWW5, J3KSY2
    5. XM_054332112.1XP_054188087.1  galectin-9C isoform X8

      UniProtKB/TrEMBL
      J3QR96
    6. XM_054332108.1XP_054188083.1  galectin-9C isoform X4

      UniProtKB/TrEMBL
      B3KWW5
    7. XM_054332110.1XP_054188085.1  galectin-9C isoform X6

      UniProtKB/TrEMBL
      B4DKP4
    8. XM_054332111.1XP_054188086.1  galectin-9C isoform X7

      UniProtKB/TrEMBL
      B4DKP4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      18423619..18441775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316967.1XP_054172942.1  galectin-9C isoform X5

      UniProtKB/TrEMBL
      J3QR96
    2. XM_054316963.1XP_054172938.1  galectin-9C isoform X1

      UniProtKB/TrEMBL
      B3KWW5
    3. XM_054316964.1XP_054172939.1  galectin-9C isoform X2

      UniProtKB/TrEMBL
      B3KWW5
    4. XM_054316965.1XP_054172940.1  galectin-9C isoform X3

      UniProtKB/TrEMBL
      B3KWW5, J3KSY2
    5. XM_054316970.1XP_054172945.1  galectin-9C isoform X8

      UniProtKB/TrEMBL
      J3QR96
    6. XM_054316966.1XP_054172941.1  galectin-9C isoform X4

      UniProtKB/TrEMBL
      B3KWW5
    7. XM_054316968.1XP_054172943.1  galectin-9C isoform X6

      UniProtKB/TrEMBL
      B4DKP4
    8. XM_054316969.1XP_054172944.1  galectin-9C isoform X7

      UniProtKB/TrEMBL
      B4DKP4