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    ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [ Homo sapiens (human) ]

    Gene ID: 64411, updated on 17-Jun-2024

    Summary

    Official Symbol
    ARAP3provided by HGNC
    Official Full Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3provided by HGNC
    Primary source
    HGNC:HGNC:24097
    See related
    Ensembl:ENSG00000120318 MIM:606647; AllianceGenome:HGNC:24097
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRAG1; CENTD3
    Summary
    This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in lung (RPKM 9.2), fat (RPKM 7.9) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARAP3 in Genome Data Viewer
    Location:
    5q31.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (141653402..141682230, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (142179417..142208259, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (141032969..141061797, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23309 Neighboring gene histone deacetylase 3 Neighboring gene Sharpr-MPRA regulatory region 64 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16457 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141029007-141029585 Neighboring gene RELT like 2 Neighboring gene FCH and double SH3 domains 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:141037429-141038628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16459 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141053759-141054426 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141054427-141055095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141071853-141072386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141072387-141072920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141080718-141081218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23312 Neighboring gene uncharacterized LOC124901092 Neighboring gene uncharacterized LOC124901093 Neighboring gene Sharpr-MPRA regulatory region 9303 Neighboring gene Sharpr-MPRA regulatory region 9103 Neighboring gene uncharacterized LOC124901094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141137138-141137707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141137708-141138276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141138277-141138846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141141594-141142094

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21065

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-3,4-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
    Names
    ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3
    Arf and Rho GAP adapter protein 3
    PtdIns(3,4,5)P3-binding protein
    centaurin-delta-3
    phosphoinositide binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046966.1 RefSeqGene

      Range
      5004..33832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_022481.6NP_071926.4  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

      See identical proteins and their annotated locations for NP_071926.4

      Status: REVIEWED

      Source sequence(s)
      AJ310567, AK024718, BC025757, BX489939
      Consensus CDS
      CCDS4266.1
      UniProtKB/Swiss-Prot
      B4DIT1, D3DQE3, Q8WWN8
      UniProtKB/TrEMBL
      A8K1Y7
      Related
      ENSP00000239440.4, ENST00000239440.9
      Conserved Domains (11) summary
      cd09490
      Location:466
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      smart00454
      Location:1264
      SAM; Sterile alpha motif
      cd04385
      Location:9091084
      RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
      cd13253
      Location:289381
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:398479
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:676786
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd13259
      Location:12121331
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      pfam00169
      Location:288379
      PH; PH domain
      pfam00788
      Location:11171209
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:490606
      ArfGap; Putative GTPase activating protein for Arf
      cl17171
      Location:846894
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      141653402..141682230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417514.1XP_047273470.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X12

      UniProtKB/TrEMBL
      G5E9Y3
    2. XM_047417513.1XP_047273469.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X11

      UniProtKB/TrEMBL
      G5E9Y3
      Related
      ENSP00000421826.1, ENST00000508305.5
    3. XM_047417512.1XP_047273468.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X10

      UniProtKB/TrEMBL
      G5E9Y3
    4. XM_047417511.1XP_047273467.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X9

      UniProtKB/TrEMBL
      G5E9Y3
    5. XM_047417510.1XP_047273466.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X8

      UniProtKB/TrEMBL
      A8K1Y7
    6. XM_005268499.2XP_005268556.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X6

      UniProtKB/TrEMBL
      A8K1Y7
      Conserved Domains (8) summary
      cd04385
      Location:8311006
      RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
      cd13253
      Location:211303
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:320401
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:598708
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      pfam00169
      Location:210301
      PH; PH domain
      pfam00788
      Location:10391131
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:412528
      ArfGap; Putative GTPase activating protein for Arf
      cl17171
      Location:11341253
      PH-like; Pleckstrin homology-like domain
    7. XM_047417509.1XP_047273465.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X7

      UniProtKB/TrEMBL
      A8K1Y7
    8. XM_047417508.1XP_047273464.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5

      UniProtKB/TrEMBL
      A8K1Y7
    9. XM_047417507.1XP_047273463.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      A8K1Y7
    10. XM_005268498.3XP_005268555.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A8K1Y7
      Conserved Domains (11) summary
      cd09490
      Location:466
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      smart00454
      Location:1264
      SAM; Sterile alpha motif
      cd04385
      Location:9091064
      RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
      cd13253
      Location:289381
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:398479
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:676786
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd13259
      Location:11921311
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      pfam00169
      Location:288379
      PH; PH domain
      pfam00788
      Location:10971189
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:490606
      ArfGap; Putative GTPase activating protein for Arf
      cl17171
      Location:846894
      PH-like; Pleckstrin homology-like domain
    11. XM_047417506.1XP_047273462.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A8K1Y7
    12. XM_047417505.1XP_047273461.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      B4DIT1, D3DQE3, Q8WWN8
      UniProtKB/TrEMBL
      A8K1Y7
    13. XM_011537677.3XP_011535979.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X13

      UniProtKB/TrEMBL
      A8K1Y7
      Related
      ENSP00000421468.1, ENST00000513878.5
      Conserved Domains (8) summary
      cd04385
      Location:714889
      RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
      cd13253
      Location:94186
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:203284
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:481591
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      pfam00169
      Location:93184
      PH; PH domain
      pfam00788
      Location:9221014
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:295411
      ArfGap; Putative GTPase activating protein for Arf
      cl17171
      Location:10171136
      PH-like; Pleckstrin homology-like domain
    14. XM_005268500.5XP_005268557.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X14

      Conserved Domains (9) summary
      cd09490
      Location:466
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      smart00454
      Location:1264
      SAM; Sterile alpha motif
      cd13253
      Location:289381
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:398479
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:676786
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      pfam00169
      Location:288379
      PH; PH domain
      pfam01412
      Location:490606
      ArfGap; Putative GTPase activating protein for Arf
      cl02570
      Location:909934
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17171
      Location:846894
      PH-like; Pleckstrin homology-like domain
    15. XM_047417515.1XP_047273471.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X15

    RNA

    1. XR_007058626.1 RNA Sequence

    2. XR_007058625.1 RNA Sequence

    3. XR_007058624.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      142179417..142208259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353120.1XP_054209095.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X12

      UniProtKB/TrEMBL
      G5E9Y3
    2. XM_054353119.1XP_054209094.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X11

      UniProtKB/TrEMBL
      G5E9Y3
    3. XM_054353118.1XP_054209093.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X10

      UniProtKB/TrEMBL
      G5E9Y3
    4. XM_054353117.1XP_054209092.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X9

      UniProtKB/TrEMBL
      G5E9Y3
    5. XM_054353116.1XP_054209091.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X8

      UniProtKB/TrEMBL
      A8K1Y7
    6. XM_054353114.1XP_054209089.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X6

      UniProtKB/TrEMBL
      A8K1Y7
    7. XM_054353112.1XP_054209087.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      A8K1Y7
    8. XM_054353115.1XP_054209090.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X7

      UniProtKB/TrEMBL
      A8K1Y7
    9. XM_054353110.1XP_054209085.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A8K1Y7
    10. XM_054353111.1XP_054209086.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A8K1Y7
    11. XM_054353113.1XP_054209088.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5

      UniProtKB/TrEMBL
      A8K1Y7
    12. XM_054353121.1XP_054209096.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X13

      UniProtKB/TrEMBL
      A8K1Y7
    13. XM_054353122.1XP_054209097.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X14

    14. XM_054353123.1XP_054209098.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X15

    RNA

    1. XR_008487146.1 RNA Sequence

    2. XR_008487145.1 RNA Sequence

    3. XR_008487144.1 RNA Sequence