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    Gulo gulonolactone (L-) oxidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60671, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Guloprovided by RGD
    Official Full Name
    gulonolactone (L-) oxidaseprovided by RGD
    Primary source
    RGD:620701
    See related
    EnsemblRapid:ENSRNOG00000016648 AllianceGenome:RGD:620701
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables L-gulonolactone oxidase activity. Predicted to be involved in L-ascorbic acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 2060.2) See more
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    Genomic context

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    See Gulo in Genome Data Viewer
    Location:
    15p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (44381226..44403314, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (40205677..40227766, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (42671206..42693711, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene scavenger receptor class A, member 3 Neighboring gene protein phosphatase 2 scaffold subunit A alpha, pseudogene 1 Neighboring gene clusterin Neighboring gene uncharacterized LOC102555773 Neighboring gene ADAM metallopeptidase domain 2 Neighboring gene epoxide hydrolase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. L-gulono-gamma-lactone oxidase is the enzyme responsible for the production of methylguanidine in the rat liver. Fujitsuka N, et al. Nephron, 1993. PMID 8459881
    2. Isolation and sequence analysis of a complementary DNA encoding rat liver L-gulono-gamma-lactone oxidase, a key enzyme for L-ascorbic acid biosynthesis. Koshizaka T, et al. J Biol Chem, 1988 Feb 5. PMID 3338984
    3. Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis. Nishikimi M, et al. Am J Clin Nutr, 1991 Dec. PMID 1962571
    4. A missense mutation of L-gulono-gamma-lactone oxidase causes the inability of scurvy-prone osteogenic disorder rats to synthesize L-ascorbic acid. Kawai T, et al. J Biol Chem, 1992 Oct 25. PMID 1400508
    5. Guinea pigs possess a highly mutated gene for L-gulono-gamma-lactone oxidase, the key enzyme for L-ascorbic acid biosynthesis missing in this species. Nishikimi M, et al. J Biol Chem, 1992 Oct 25. PMID 1400507

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-arabinono-1,4-lactone oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-gulonolactone oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-gulonolactone oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-gulonolactone oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables flavin adenine dinucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-ascorbic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-ascorbic acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    L-gulonolactone oxidase
    Names
    GLO
    L-gulono-gamma-lactone oxidase
    LGO
    NP_071556.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022220.2 → NP_071556.2  L-gulonolactone oxidase

      See identical proteins and their annotated locations for NP_071556.2

      Status: PROVISIONAL

      Source sequence(s)
      BC089803
      UniProtKB/Swiss-Prot
      P10867, Q5EBC1, Q64597, Q9QWR6
      UniProtKB/TrEMBL
      A0A140TAC7, A6K6L4
      Related
      ENSRNOP00000022703.4, ENSRNOT00000022702.8
      Conserved Domains (3) summary
      TIGR01678
      Location:7 → 433
      FAD_lactone_ox; sugar 1,4-lactone oxidases
      pfam01565
      Location:21 → 156
      FAD_binding_4; FAD binding domain
      pfam04030
      Location:180 → 438
      ALO; D-arabinono-1,4-lactone oxidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      44381226..44403314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10867.3 GenPept UniProtKB/Swiss-Prot:P10867

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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