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    TSKS testis specific serine kinase substrate [ Homo sapiens (human) ]

    Gene ID: 60385, updated on 5-Mar-2024

    Summary

    Official Symbol
    TSKSprovided by HGNC
    Official Full Name
    testis specific serine kinase substrateprovided by HGNC
    Primary source
    HGNC:HGNC:30719
    See related
    Ensembl:ENSG00000126467 MIM:608253; AllianceGenome:HGNC:30719
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TSKS1; TSSKS; STK22S1; PPP1R161
    Summary
    This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 31.5) See more
    Orthologs
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    Genomic context

    See TSKS in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49739760..49763306, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52739905..52763451, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50243017..50266563, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene carnitine palmitoyltransferase 1C Neighboring gene CRISPRi-validated cis-regulatory element chr19.5489 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50224617-50225117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50230322-50230822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50230823-50231323 Neighboring gene ribosomal protein S9 pseudogene 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:50237036-50237211 Neighboring gene Sharpr-MPRA regulatory region 2111 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50249425-50249944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50249945-50250464 Neighboring gene uncharacterized LOC105372434 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:50263738-50263955 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50264724-50265316 Neighboring gene hESC enhancers GRCh37_chr19:50268923-50269900 and GRCh37_chr19:50269954-50270722 Neighboring gene RNA, U6 small nuclear 841, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50274662-50275586 Neighboring gene adaptor related protein complex 2 subunit alpha 1 Neighboring gene microRNA 6799

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    testis-specific serine kinase substrate
    Names
    STK22 substrate 1
    protein phosphatase 1, regulatory subunit 161
    testis specific serine/threonine kinase substrate
    testis-specific kinase substrate

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021733.2NP_068379.1  testis-specific serine kinase substrate

      See identical proteins and their annotated locations for NP_068379.1

      Status: REVIEWED

      Source sequence(s)
      AC011495
      Consensus CDS
      CCDS12780.1
      UniProtKB/Swiss-Prot
      Q8WXJ0, Q9UJT2
      Related
      ENSP00000246801.2, ENST00000246801.8
      Conserved Domains (1) summary
      pfam15358
      Location:26592
      TSKS; Testis-specific serine kinase substrate

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      49739760..49763306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      52739905..52763451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)