atl1 atlastin GTPase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atl1provided by ZNC
Official Full Name: atlastin GTPase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8003
See related: Ensembl:ENSDARG00000060481 AllianceGenome:ZFIN:ZDB-GENE-030131-8003
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj46c01; wu:fj46c01
Summary: Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within axon guidance; determination of dorsal identity; and negative regulation of BMP signaling pathway. Located in late endosome. Is expressed in brain; primary motor neurons; skeletal muscle; and spinal cord neural tube. Human ortholog(s) of this gene implicated in hereditary sensory neuropathy type 1D and hereditary spastic paraplegia 3A. Orthologous to human ATL1 (atlastin GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (36764705..36784400)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (36638713..36658568)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study suggests that atlastin may regulate BMP receptor trafficking. and genetic or pharmacological inhibition of BMP signaling was sufficient to rescue the loss of mobility and spinal motor axon defects of atl1 morphants.
Title: Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of dorsal identity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within determination of dorsal identity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: atlastin-1

NP_001139172.1

EC 3.6.5.-

XP_005157066.1

EC 3.6.5.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145700.1 → NP_001139172.1 atlastin-1

Status: PROVISIONAL

Source sequence(s)

BX936452

UniProtKB/TrEMBL

A0A8M1NQA6, B8A6H1

Related

ENSDARP00000101056.3, ENSDART00000111832.5

Conserved Domains (1) summary

cl21455
Location:44 → 306

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

36764705..36784400

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005157009.5 → XP_005157066.1 atlastin-1 isoform X1

UniProtKB/TrEMBL

A0A8M2B377, E9QGX9

Related

ENSDARP00000079665.4, ENSDART00000085230.6

Conserved Domains (1) summary

cl21455
Location:44 → 306

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases