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    psda pleckstrin and Sec7 domain containing a [ Danio rerio (zebrafish) ]

    Gene ID: 570918, updated on 25-Apr-2024

    Summary

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    Official Symbol
    psdaprovided by ZNC
    Official Full Name
    pleckstrin and Sec7 domain containing aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090313-44
    See related
    Ensembl:ENSDARG00000078102 AllianceGenome:ZFIN:ZDB-GENE-090313-44
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-150i13.1
    Summary
    Predicted to enable phospholipid binding activity. Predicted to act upstream of or within regulation of ARF protein signal transduction. Predicted to be located in ruffle membrane. Orthologous to human PSD (pleckstrin and Sec7 domain containing). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (22737086..22812953, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (22606947..22682519, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene glutamate dehydrogenase 1a Neighboring gene shieldin complex subunit 2 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) Neighboring gene uncharacterized LOC100001713 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene phenazine biosynthesis like protein domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PH and SEC7 domain-containing protein 1; uncharacterized protein si:ch211-150i13.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      22737086..22812953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009307379.3 → XP_009305654.1  uncharacterized protein si:ch211-150i13.1 isoform X1

      See identical proteins and their annotated locations for XP_009305654.1

      UniProtKB/TrEMBL
      A0A8M9PU72
      Conserved Domains (2) summary
      cd00171
      Location:1136 → 1288
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:1332 → 1456
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    2. XM_009307381.3 → XP_009305656.1  uncharacterized protein si:ch211-150i13.1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q1B0
      Conserved Domains (2) summary
      cd00171
      Location:1128 → 1280
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:1324 → 1448
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    3. XM_009307378.3 → XP_009305653.1  uncharacterized protein si:ch211-150i13.1 isoform X1

      See identical proteins and their annotated locations for XP_009305653.1

      UniProtKB/TrEMBL
      A0A8M9PU72
      Conserved Domains (2) summary
      cd00171
      Location:1136 → 1288
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:1332 → 1456
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    4. XM_005156914.4 → XP_005156971.1  PH and SEC7 domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A2R8RNF7, A0A8M2B3Q5
      Related
      ENSDARP00000149269.1, ENSDART00000189320.1
      Conserved Domains (2) summary
      cd00171
      Location:62 → 214
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:258 → 382
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    5. XM_005156915.4 → XP_005156972.1  PH and SEC7 domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PN09, F1QCL5
      Related
      ENSDARP00000098718.4, ENSDART00000112900.4
      Conserved Domains (2) summary
      cd00171
      Location:52 → 204
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:248 → 372
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394884.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      180544..260335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472729.1 → XP_021328404.1  uncharacterized protein si:ch211-150i13.1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PU72
      Conserved Domains (2) summary
      cd00171
      Location:1136 → 1288
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:1332 → 1456
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    2. XM_021472730.1 → XP_021328405.1  uncharacterized protein si:ch211-150i13.1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PU72
      Conserved Domains (2) summary
      cd00171
      Location:1136 → 1288
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:1332 → 1456
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    3. XM_021472731.1 → XP_021328406.1  uncharacterized protein si:ch211-150i13.1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q1B0
      Conserved Domains (2) summary
      cd00171
      Location:1128 → 1280
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:1324 → 1448
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    4. XM_021472728.1 → XP_021328403.1  uncharacterized protein si:ch211-150i13.1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PU72
      Conserved Domains (2) summary
      cd00171
      Location:1136 → 1288
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:1332 → 1456
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    5. XM_021472732.1 → XP_021328407.1  PH and SEC7 domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A2R8RNF7, A0A8M2B3Q5
      Conserved Domains (2) summary
      cd00171
      Location:62 → 214
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:258 → 382
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    6. XM_021472733.1 → XP_021328408.1  PH and SEC7 domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PN09, F1QCL5
      Conserved Domains (2) summary
      cd00171
      Location:52 → 204
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:248 → 372
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
    Nucleotide Protein
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