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    Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor [ Mus musculus (house mouse) ]

    Gene ID: 56876, updated on 21-Apr-2024

    Summary

    Official Symbol
    Nsmfprovided by MGI
    Official Full Name
    NMDA receptor synaptonuclear signaling and neuronal migration factorprovided by MGI
    Primary source
    MGI:MGI:1861755
    See related
    Ensembl:ENSMUSG00000006476 AllianceGenome:MGI:1861755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nelf; Jacob
    Summary
    Predicted to enable calcium-dependent protein binding activity. Involved in cellular response to gonadotropin stimulus. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; lung; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia and hypogonadotropic hypogonadism 9 with or without anosmia. Orthologous to human NSMF (NMDA receptor synaptonuclear signaling and neuronal migration factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cortex adult (RPKM 150.5), frontal lobe adult (RPKM 133.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    2 A3; 2 16.94 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24944370..24952893)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25054361..25062881)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene patatin-like phospholipase domain containing 7 Neighboring gene predicted gene, 25518 Neighboring gene predicted gene, 24875 Neighboring gene STARR-positive B cell enhancer ABC_E4419 Neighboring gene microRNA 7664 Neighboring gene STARR-seq mESC enhancer starr_03956 Neighboring gene predicted gene, 39770 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 8 Neighboring gene NADPH oxidase activator 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    part_of euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NMDA receptor synaptonuclear signaling and neuronal migration factor
    Names
    juxtasynaptic attractor of caldendrin on dendritic boutons protein
    nasal embryonic LHRH factor
    nasal embryonic luteinizing hormone-releasing hormone factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039386.2NP_001034475.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform A

      See identical proteins and their annotated locations for NP_001034475.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform A.
      Source sequence(s)
      AL732585
      Consensus CDS
      CCDS15745.1
      UniProtKB/Swiss-Prot
      A2AJ93, A2AJ94, Q8BPT0, Q8C9R5, Q99NF2, Q9DBF4, Q9ERZ1
      UniProtKB/TrEMBL
      F6TKU5
      Related
      ENSMUSP00000097908.5, ENSMUST00000100334.11
    2. NM_001039387.2NP_001034476.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform B

      See identical proteins and their annotated locations for NP_001034476.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame exon, compared to variant 1. The resulting protein (isoform B) is shorter when it is compared to isoform A.
      Source sequence(s)
      AL732585
      Consensus CDS
      CCDS15746.1
      UniProtKB/TrEMBL
      F6TKU5
      Related
      ENSMUSP00000006646.9, ENSMUST00000006646.15
    3. NM_001177654.2NP_001171125.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform D

      See identical proteins and their annotated locations for NP_001171125.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate, in-frame exon and uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform C) is shorter when it is compared to isoform A.
      Source sequence(s)
      AL732585
      UniProtKB/TrEMBL
      F6TKU5, Q3TNG2
    4. NM_001177655.2NP_001171126.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform E

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two alternate, in-frame exons, compared to variant 1. The resulting protein (isoform E) is shorter when it is compared to isoform A.
      Source sequence(s)
      AL732585
      Consensus CDS
      CCDS50523.1
      UniProtKB/TrEMBL
      A2AJ96, F6TKU5
      Related
      ENSMUSP00000110030.2, ENSMUST00000114388.8
    5. NM_001421788.1NP_001408717.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform F

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) encodes the longest isoform (F).
      Source sequence(s)
      AL732585
    6. NM_001421790.1NP_001408719.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform G

      Status: VALIDATED

      Source sequence(s)
      AL732585
    7. NM_001421791.1NP_001408720.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform H

      Status: VALIDATED

      Source sequence(s)
      AL732585
    8. NM_001421793.1NP_001408722.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform I

      Status: VALIDATED

      Source sequence(s)
      AL732585
      UniProtKB/TrEMBL
      A2AJ92
    9. NM_001421796.1NP_001408725.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform J

      Status: VALIDATED

      Source sequence(s)
      AL732585
    10. NM_001421798.1NP_001408727.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform K

      Status: VALIDATED

      Source sequence(s)
      AL732585
    11. NM_001421800.1NP_001408729.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform L

      Status: VALIDATED

      Source sequence(s)
      AL732585
    12. NM_001421802.1NP_001408731.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform M

      Status: VALIDATED

      Source sequence(s)
      AL732585
    13. NM_001421803.1NP_001408732.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform N

      Status: VALIDATED

      Source sequence(s)
      AL732585
    14. NM_020276.4NP_064672.2  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform C

      See identical proteins and their annotated locations for NP_064672.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate, in-frame exon, compared to variant 1. The resulting protein (isoform B) is shorter when it is compared to isoform A.
      Source sequence(s)
      AL732585
      Consensus CDS
      CCDS15747.1
      UniProtKB/TrEMBL
      F6TKU5
      Related
      ENSMUSP00000099995.5, ENSMUST00000102931.11

    RNA

    1. NR_185326.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL732585

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      24944370..24952893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498201.3XP_006498264.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform X2

      UniProtKB/TrEMBL
      F6TKU5
    2. XM_006498202.5XP_006498265.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform X3

      UniProtKB/TrEMBL
      A2AJ95, F6TKU5
      Related
      ENSMUSP00000110028.2, ENSMUST00000114386.8
    3. XM_006498203.5XP_006498266.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform X4

      UniProtKB/TrEMBL
      F6TKU5
    4. XM_030251903.2XP_030107763.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform X5

    5. XM_030251905.2XP_030107765.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform X7