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    Nfu1 NFU1 iron-sulfur cluster scaffold [ Mus musculus (house mouse) ]

    Gene ID: 56748, updated on 23-May-2018

    Summary

    Official Symbol
    Nfu1provided by MGI
    Official Full Name
    NFU1 iron-sulfur cluster scaffoldprovided by MGI
    Primary source
    MGI:MGI:1913290
    See related
    Ensembl:ENSMUSG00000029993 Vega:OTTMUSG00000029692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CGI-33; Hirip5; 0610006G17Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 20.2), CNS E18 (RPKM 18.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nfu1 in Genome Data Viewer
    Location:
    6; 6 D1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (87009291..87028461)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (86959830..86978455)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2610306M01 gene Neighboring gene AP2 associated kinase 1 Neighboring gene predicted gene, 38495 Neighboring gene glutamine fructose-6-phosphate transaminase 1 Neighboring gene DNA segment, Chr 6, ERATO Doi 527, expressed

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
    Names
    HIRA-interacting protein 5
    histone cell cycle regulation defective interacting protein 5
    mHIRIP5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170591.1NP_001164062.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_001164062.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK145558, CD775268
      Consensus CDS
      CCDS51836.1
      UniProtKB/Swiss-Prot
      Q9QZ23
      UniProtKB/TrEMBL
      A0A0N4SUH8
      Related
      ENSMUSP00000032060.8, ENSMUST00000032060.14
      Conserved Domains (2) summary
      smart00932
      Location:59146
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      pfam01106
      Location:174240
      NifU; NifU-like domain
    2. NM_020045.3NP_064429.2  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_064429.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1, which results in a protein (isoform 2) that is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK003730, AK145558, CD775268
      Consensus CDS
      CCDS85088.1
      UniProtKB/Swiss-Prot
      Q9QZ23
      Related
      ENSMUSP00000113332.2, OTTMUSP00000038171, ENSMUST00000117583.7, OTTMUST00000073668
      Conserved Domains (2) summary
      smart00932
      Location:59146
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      pfam01106
      Location:173239
      NifU; NifU-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      87009291..87028461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506419.1XP_006506482.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X3

      See identical proteins and their annotated locations for XP_006506482.1

      UniProtKB/Swiss-Prot
      Q9QZ23
      UniProtKB/TrEMBL
      A0A0N4SUH8
      Related
      ENSMUSP00000113637.2, OTTMUSP00000038172, ENSMUST00000120240.7, OTTMUST00000073669
      Conserved Domains (2) summary
      smart00932
      Location:59146
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      pfam01106
      Location:174240
      NifU; NifU-like domain
    2. XM_006506420.1XP_006506483.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X4

      See identical proteins and their annotated locations for XP_006506483.1

      UniProtKB/Swiss-Prot
      Q9QZ23
      Conserved Domains (2) summary
      smart00932
      Location:59146
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      pfam01106
      Location:173239
      NifU; NifU-like domain
    3. XM_011241416.2XP_011239718.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X1

      Conserved Domains (2) summary
      smart00932
      Location:59219
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      pfam01106
      Location:247313
      NifU; NifU-like domain
    4. XM_011241417.2XP_011239719.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X2

      Conserved Domains (2) summary
      smart00932
      Location:59219
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      pfam01106
      Location:246312
      NifU; NifU-like domain
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