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    Rbx1 ring-box 1 [ Mus musculus (house mouse) ]

    Gene ID: 56438, updated on 9-Sep-2018

    Summary

    Official Symbol
    Rbx1provided by MGI
    Official Full Name
    ring-box 1provided by MGI
    Primary source
    MGI:MGI:1891829
    See related
    Ensembl:ENSMUSG00000022400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ROC1; AA517855; 1500002P15Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 43.0), CNS E14 (RPKM 40.8) and 26 other tissues See more
    Orthologs

    Genomic context

    See Rbx1 in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (81466316..81476369)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (81296746..81306799)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene X-prolyl aminopeptidase 3, mitochondrial Neighboring gene DnaJ heat shock protein family (Hsp40) member B7 Neighboring gene predicted gene 17025 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene E1A binding protein p300

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NEDD8 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    eukaryotic initiation factor 4E binding TAS
    Traceable Author Statement
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    ubiquitin-ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein monoubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Cul7-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SCF ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    VCB complex ISO
    Inferred from Sequence Orthology
    more info
     
    anaphase-promoting complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cullin-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cullin-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin ligase complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RBX1
    Names
    E3 ubiquitin-protein transferase RBX1
    RING finger protein 75
    ring-box protein 1
    NP_062686.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019712.3NP_062686.1  E3 ubiquitin-protein ligase RBX1

      See identical proteins and their annotated locations for NP_062686.1

      Status: VALIDATED

      Source sequence(s)
      BB807275, BC056992, CB522825, CJ082632
      Consensus CDS
      CCDS49676.1
      UniProtKB/Swiss-Prot
      P62878
      Related
      ENSMUSP00000023036.5, ENSMUST00000023036.6
      Conserved Domains (1) summary
      cd16485
      Location:40101
      mRING-H2-C3H2C2D_RBX1; modified RING finger, H2 subclass (C3H2C2D-type), found in RING-box protein 1 (RBX1) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      81466316..81476369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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