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    LTB4R2 leukotriene B4 receptor 2 [ Homo sapiens (human) ]

    Gene ID: 56413, updated on 17-Jun-2024

    Summary

    Official Symbol
    LTB4R2provided by HGNC
    Official Full Name
    leukotriene B4 receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:19260
    See related
    Ensembl:ENSG00000213906 MIM:605773; AllianceGenome:HGNC:19260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BLT2; NOP9; BLTR2; JULF2; KPG_004; LTB4-R2; LTB4-R 2
    Summary
    Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in inflammatory response and neuropeptide signaling pathway. Predicted to act upstream of or within keratinocyte migration and signal transduction. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in skin (RPKM 12.7), spleen (RPKM 9.3) and 21 other tissues See more
    Orthologs
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    Genomic context

    See LTB4R2 in Genome Data Viewer
    Location:
    14q12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24310140..24312038)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18508483..18510381)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24779346..24781244)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene TGM1 promoter region Neighboring gene Rab geranylgeranyltransferase subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8209 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:24747863-24748093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8210 Neighboring gene NOP9 nucleolar protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8213 Neighboring gene nonconserved acetylation island sequence 81 enhancer Neighboring gene dehydrogenase/reductase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5636 Neighboring gene cell death inducing DFFA like effector b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24785286-24785786 Neighboring gene leukotriene B4 receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24790818-24791777 Neighboring gene adenylate cyclase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5637 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5639 Neighboring gene Sharpr-MPRA regulatory region 10023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8216 Neighboring gene receptor interacting serine/threonine kinase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables leukotriene B4 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables leukotriene receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in keratinocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukotriene signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    leukotriene B4 receptor 2
    Names
    LTB4 receptor JULF2
    leukotriene B4 receptor BLT2
    seven transmembrane receptor BLTR2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164692.3NP_001158164.1  leukotriene B4 receptor 2

      See identical proteins and their annotated locations for NP_001158164.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK304169, AL096870, BC038437, DC408599
      Consensus CDS
      CCDS9625.2
      UniProtKB/Swiss-Prot
      Q5KU28, Q9NPC1, Q9NPE5
      UniProtKB/TrEMBL
      B4E292
      Related
      ENSP00000445772.1, ENST00000543919.1
      Conserved Domains (2) summary
      cd14964
      Location:2347
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:21300
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. NM_019839.5NP_062813.2  leukotriene B4 receptor 2

      See identical proteins and their annotated locations for NP_062813.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB032558, AK304169, AL096870, DC408599
      Consensus CDS
      CCDS9625.2
      UniProtKB/Swiss-Prot
      Q5KU28, Q9NPC1, Q9NPE5
      UniProtKB/TrEMBL
      B4E292
      Related
      ENSP00000433290.1, ENST00000533293.2
      Conserved Domains (2) summary
      cd14964
      Location:2347
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:21300
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      24310140..24312038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654722.1 Reference GRCh38.p14 PATCHES

      Range
      611118..613016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      18508483..18510381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001164693.1: Suppressed sequence

      Description
      NM_001164693.1: This RefSeq was permanently suppressed because there is not sufficient data to support splicing of an intron with non-consensus splice sites in the CDS.