U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PRB3 proline rich protein BstNI subfamily 3 [ Homo sapiens (human) ]

    Gene ID: 5544, updated on 7-Apr-2024

    Summary

    Official Symbol
    PRB3provided by HGNC
    Official Full Name
    proline rich protein BstNI subfamily 3provided by HGNC
    Primary source
    HGNC:HGNC:9339
    See related
    Ensembl:ENSG00000197870 MIM:168840; AllianceGenome:HGNC:9339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G1; PRG
    Summary
    This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Long" allele. The protein isoforms encoded by this gene are recognized as the "first line of oral defense" against the detrimental effects of polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015]
    Expression
    Restricted expression toward salivary gland (RPKM 9550.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PRB3 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (11265914..11269707, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (11135147..11138817, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11418847..11422641, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987435 Neighboring gene taste 2 receptor member 7 pseudogene Neighboring gene taste 2 receptor member 42 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:11443165-11443666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:11443667-11444166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:11450808-11451403 Neighboring gene proline rich protein BstNI subfamily 4 Neighboring gene proline rich protein BstNI subfamily 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC116862, MGC116863, MGC116864

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in defense response to Gram-negative bacterium NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    basic salivary proline-rich protein 3
    Names
    BstNI type basic salivary proline-rich protein 3
    G1 parotid salivary glycoprotein
    parotid salivary glycoprotein G1
    proline-rich protein G1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013305.2 RefSeqGene

      Range
      5001..8794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001394862.1NP_001381791.1  basic salivary proline-rich protein 3 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC010176, AC244131
      Consensus CDS
      CCDS91655.1
      UniProtKB/Swiss-Prot
      F5H7C1, Q04118, Q15188, Q4VAY3, Q4VAY4, Q7M4M9, Q9UCT9
      Related
      ENSP00000442626.2, ENST00000538488.3
      Conserved Domains (1) summary
      PRK07764
      Location:50264
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
    2. NM_006249.5NP_006240.4  basic salivary proline-rich protein 3 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC010176, AC244131
      UniProtKB/TrEMBL
      A0A0G2JNB4
      Conserved Domains (2) summary
      pfam10240
      Location:44108
      DUF2464; Protein of unknown function (DUF2464)
      pfam15240
      Location:7188
      Pro-rich; Proline-rich

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      11265914..11269707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      460877..464670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      11135147..11138817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)