PRB3 proline rich protein BstNI subfamily 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRB3provided by HGNC
Official Full Name: proline rich protein BstNI subfamily 3provided by HGNC
Primary source: HGNC:HGNC:9339
See related: Ensembl:ENSG00000197870 MIM:168840; AllianceGenome:HGNC:9339
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: G1; PRG
Summary: This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Long" allele. The protein isoforms encoded by this gene are recognized as the "first line of oral defense" against the detrimental effects of polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015]
Expression: Restricted expression toward salivary gland (RPKM 9550.6) See more
Orthologs: all
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Genomic context

Location:: 12p13.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (11265914..11269707, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (11135147..11138817, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (11418847..11422641, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of this study suggested that low levels of PRB3 mRNA may have a role in dopamine-agonist resistance and tumor recurrence of prolactinomas.
Title: Low levels of PRB3 mRNA are associated with dopamine-agonist resistance and tumor recurrence in prolactinomas.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-X07881 (e-PCR)
- UniSTS:28431

RH77972 (e-PCR)
- UniSTS:27924

GDB:214813 (e-PCR)
- UniSTS:156185

NoName (e-PCR)
- UniSTS:483925

NoName (e-PCR)
- UniSTS:481879

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in defense response to Gram-negative bacterium	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: basic salivary proline-rich protein 3

Names: BstNI type basic salivary proline-rich protein 3; G1 parotid salivary glycoprotein; parotid salivary glycoprotein G1; proline-rich protein G1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013305.2 RefSeqGene

Range

5001..8794

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001394862.1 → NP_001381791.1 basic salivary proline-rich protein 3 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC010176, AC244131

Consensus CDS

CCDS91655.1

UniProtKB/Swiss-Prot

F5H7C1, Q04118, Q15188, Q4VAY3, Q4VAY4, Q7M4M9, Q9UCT9

Related

ENSP00000442626.2, ENST00000538488.3

Conserved Domains (1) summary

PRK07764
Location:50 → 264

PRK07764; DNA polymerase III subunits gamma and tau; Validated
NM_006249.5 → NP_006240.4 basic salivary proline-rich protein 3 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC010176, AC244131

UniProtKB/TrEMBL

A0A0G2JNB4

Conserved Domains (2) summary

pfam10240
Location:44 → 108

DUF2464; Protein of unknown function (DUF2464)

pfam15240
Location:7 → 188

Pro-rich; Proline-rich