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    Pqbp1 polyglutamine binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 54633, updated on 2-Oct-2018

    Summary

    Official Symbol
    Pqbp1provided by MGI
    Official Full Name
    polyglutamine binding protein 1provided by MGI
    Primary source
    MGI:MGI:1859638
    See related
    Ensembl:ENSMUSG00000031157 Vega:OTTMUSG00000018001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sfc2; npw38; PQBP-1
    Expression
    Ubiquitous expression in CNS E14 (RPKM 52.5), CNS E11.5 (RPKM 48.3) and 27 other tissues See more
    Orthologs

    Genomic context

    See Pqbp1 in Genome Data Viewer
    Location:
    X A1.1; X 3.56 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (7894519..7899269, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (7471649..7476354, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene proviral integration site 2 Neighboring gene solute carrier family 35 (UDP-galactose transporter), member A2 Neighboring gene translocase of inner mitochondrial membrane 17b Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor Neighboring gene ES cell-expressed Ras

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    ciliary base ISO
    Inferred from Sequence Orthology
    more info
     
    cilium ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    polyglutamine-binding protein 1
    Names
    38 kDa nuclear protein containing a WW domain
    polyglutamine tract-binding protein 1
    scurfy candidate 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252528.1NP_001239457.1  polyglutamine-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001239457.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AW488646, CD741483, CJ143105, CN718083
      Consensus CDS
      CCDS29977.1
      UniProtKB/Swiss-Prot
      Q91VJ5
      UniProtKB/TrEMBL
      A2AER7
      Related
      ENSMUSP00000123657.1, OTTMUSP00000019534, ENSMUST00000156741.7, OTTMUST00000043475
      Conserved Domains (1) summary
      smart00456
      Location:4778
      WW; Domain with 2 conserved Trp (W) residues
    2. NM_001252529.1NP_001239458.1  polyglutamine-binding protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an upstream, in-frame start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK077652, AW488646, BQ550428
      UniProtKB/Swiss-Prot
      Q91VJ5
      Conserved Domains (1) summary
      smart00456
      Location:78109
      WW; Domain with 2 conserved Trp (W) residues
    3. NM_019478.4NP_062351.2  polyglutamine-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_062351.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AL671978, AW456196, AW488646, BC157976
      Consensus CDS
      CCDS29977.1
      UniProtKB/Swiss-Prot
      Q91VJ5
      UniProtKB/TrEMBL
      A2AER7
      Related
      ENSMUSP00000111319.1, OTTMUSP00000019535, ENSMUST00000115655.7, OTTMUST00000043476
      Conserved Domains (1) summary
      smart00456
      Location:4778
      WW; Domain with 2 conserved Trp (W) residues

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      7894519..7899269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527654.1XP_006527717.1  polyglutamine-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006527717.1

      UniProtKB/Swiss-Prot
      Q91VJ5
      UniProtKB/TrEMBL
      A2AER7
      Conserved Domains (1) summary
      smart00456
      Location:4778
      WW; Domain with 2 conserved Trp (W) residues
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