Format

Send to:

Choose Destination
    • Showing Current items.

    Sdcbp syndecan binding protein [ Mus musculus (house mouse) ]

    Gene ID: 53378, updated on 31-Jan-2019

    Summary

    Official Symbol
    Sdcbpprovided by MGI
    Official Full Name
    syndecan binding proteinprovided by MGI
    Primary source
    MGI:MGI:1337026
    See related
    Ensembl:ENSMUSG00000028249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sycl; MDA-9; syntenin-1
    Expression
    Ubiquitous expression in placenta adult (RPKM 62.3), bladder adult (RPKM 56.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Sdcbp in Genome Data Viewer
    Location:
    4; 4 A1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (6365680..6396122)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (6292827..6323269)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 7, subfamily a, polypeptide 1 Neighboring gene RIKEN cDNA 4930430E12 gene Neighboring gene neutral sphingomyelinase (N-SMase) activation associated factor Neighboring gene coiled-coil-helix-coiled-coil-helix domain-containing protein 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    frizzled binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-5 receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    neurexin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    syndecan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    syndecan binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Ras protein signal transduction IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of extracellular exosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pathway-restricted SMAD protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of pathway-restricted SMAD protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-5 receptor complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    syntenin-1
    Names
    scaffold protein Pbp1
    syndecan interacting protein
    syndecan-binding protein 1
    syntenin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098227.1NP_001091697.1  syntenin-1 isoform 1

      See identical proteins and their annotated locations for NP_001091697.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK150278, BB736053, BY387130, BY757323, BY779386, W65143
      Consensus CDS
      CCDS51110.1
      UniProtKB/Swiss-Prot
      O08992
      Related
      ENSMUSP00000029912.4, ENSMUST00000029912.10
      Conserved Domains (1) summary
      cd00992
      Location:113192
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. NM_016807.2NP_058087.2  syntenin-1 isoform 2

      See identical proteins and their annotated locations for NP_058087.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AK150278, BB736053, BY387130, BY757323, BY779386, W65143
      Consensus CDS
      CCDS17951.1
      UniProtKB/Swiss-Prot
      O08992
      UniProtKB/TrEMBL
      Q3TMX0
      Related
      ENSMUSP00000100073.5, ENSMUST00000103008.11
      Conserved Domains (1) summary
      cd00992
      Location:112191
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      6365680..6396122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538084.3XP_006538147.1  syntenin-1 isoform X1

      See identical proteins and their annotated locations for XP_006538147.1

      UniProtKB/Swiss-Prot
      O08992
      Related
      ENSMUSP00000135777.1, ENSMUST00000175769.7
      Conserved Domains (1) summary
      cd00992
      Location:113192
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    Support Center