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    ASB2 ankyrin repeat and SOCS box containing 2 [ Homo sapiens (human) ]

    Gene ID: 51676, updated on 17-Jun-2024

    Summary

    Official Symbol
    ASB2provided by HGNC
    Official Full Name
    ankyrin repeat and SOCS box containing 2provided by HGNC
    Primary source
    HGNC:HGNC:16012
    See related
    Ensembl:ENSG00000100628 MIM:605759; AllianceGenome:HGNC:16012
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASB-2
    Summary
    This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
    Expression
    Biased expression in heart (RPKM 15.5), prostate (RPKM 8.6) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ASB2 in Genome Data Viewer
    Location:
    14q32.12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (93934166..93976570, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (88161475..88203881, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94400512..94442916, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:94346537-94347036 Neighboring gene uncharacterized LOC105370631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94357084-94358061 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94359097-94359871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94359872-94360645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94362555-94363054 Neighboring gene FAM181A antisense RNA 1 Neighboring gene family with sequence similarity 181 member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94407532-94408032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94408033-94408533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94420244-94421221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94421332-94422038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94422039-94422743 Neighboring gene microRNA 4506 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:94425411-94426610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94428828-94429328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94429329-94429829 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94441397-94441968 Neighboring gene uncharacterized LOC107984663 Neighboring gene uncharacterized LOC124903368 Neighboring gene coiled-coil domain containing 197

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC40044

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cullin family protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cardiac muscle cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendritic cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in podosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in skeletal muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ankyrin repeat and SOCS box protein 2
    Names
    ankyrin repeat and SOCS box-containing protein 2a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202429.2NP_001189358.1  ankyrin repeat and SOCS box protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001189358.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB488462
      Consensus CDS
      CCDS55940.1
      UniProtKB/Swiss-Prot
      B2RDP9, B4E166, Q96Q27, Q9NSU5, Q9Y567
      UniProtKB/TrEMBL
      B3KPZ6
      Related
      ENSP00000451575.1, ENST00000555019.6
      Conserved Domains (5) summary
      cd03721
      Location:591635
      SOCS_ASB2; SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been ...
      sd00045
      Location:237268
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:443469
      Ank; Ankyrin repeat
      pfam12796
      Location:109202
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:198432
      Ank_2; Ankyrin repeats (3 copies)
    2. NM_016150.5NP_057234.2  ankyrin repeat and SOCS box protein 2 isoform 2

      See identical proteins and their annotated locations for NP_057234.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AJ251238, BC032354
      Consensus CDS
      CCDS9915.1
      UniProtKB/TrEMBL
      B3KPZ6
      Related
      ENSP00000320675.4, ENST00000315988.8
      Conserved Domains (4) summary
      cd00204
      Location:184309
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03721
      Location:543587
      SOCS_ASB2; SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been ...
      sd00045
      Location:189220
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:59109
      Ank_4; Ankyrin repeats (many copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      93934166..93976570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431473.1XP_047287429.1  ankyrin repeat and SOCS box protein 2 isoform X4

      UniProtKB/TrEMBL
      B3KPZ6
    2. XM_017021369.3XP_016876858.1  ankyrin repeat and SOCS box protein 2 isoform X2

      UniProtKB/TrEMBL
      B3KPZ6
      Conserved Domains (5) summary
      COG0666
      Location:65201
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd03721
      Location:556600
      SOCS_ASB2; SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been ...
      sd00045
      Location:202233
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:376426
      Ank_4; Ankyrin repeats (many copies)
      cl39094
      Location:163397
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_011536834.4XP_011535136.1  ankyrin repeat and SOCS box protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011535136.1

      UniProtKB/TrEMBL
      B3KPZ6
      Conserved Domains (4) summary
      cd00204
      Location:180305
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03721
      Location:539583
      SOCS_ASB2; SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been ...
      pfam12796
      Location:256344
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:185216
      ANK; ANK repeat [structural motif]
    4. XM_005267758.4XP_005267815.1  ankyrin repeat and SOCS box protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005267815.1

      UniProtKB/Swiss-Prot
      B2RDP9, B4E166, Q96Q27, Q9NSU5, Q9Y567
      UniProtKB/TrEMBL
      B3KPZ6
      Conserved Domains (5) summary
      cd03721
      Location:591635
      SOCS_ASB2; SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been ...
      sd00045
      Location:237268
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:443469
      Ank; Ankyrin repeat
      pfam12796
      Location:109202
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:198432
      Ank_2; Ankyrin repeats (3 copies)
    5. XM_011536835.4XP_011535137.1  ankyrin repeat and SOCS box protein 2 isoform X5

      See identical proteins and their annotated locations for XP_011535137.1

      UniProtKB/TrEMBL
      G3V2Z2
      Related
      ENSP00000450940.1, ENST00000555507.5
      Conserved Domains (4) summary
      cd00204
      Location:130255
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:206294
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:135166
      ANK; ANK repeat [structural motif]
      cl02533
      Location:489533
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187601.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1048728..1091132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328983.1XP_054184958.1  ankyrin repeat and SOCS box protein 2 isoform X4

      UniProtKB/TrEMBL
      B3KPZ6
    2. XM_054328981.1XP_054184956.1  ankyrin repeat and SOCS box protein 2 isoform X2

      UniProtKB/TrEMBL
      B3KPZ6
    3. XM_054328982.1XP_054184957.1  ankyrin repeat and SOCS box protein 2 isoform X3

      UniProtKB/TrEMBL
      B3KPZ6
    4. XM_054328980.1XP_054184955.1  ankyrin repeat and SOCS box protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RDP9, B4E166, Q96Q27, Q9NSU5, Q9Y567
      UniProtKB/TrEMBL
      B3KPZ6
    5. XM_054328984.1XP_054184959.1  ankyrin repeat and SOCS box protein 2 isoform X5

      UniProtKB/TrEMBL
      G3V2Z2
    6. XM_054328985.1XP_054184960.1  ankyrin repeat and SOCS box protein 2 isoform X6

      UniProtKB/TrEMBL
      G3V2Z2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      88161475..88203881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376214.1XP_054232189.1  ankyrin repeat and SOCS box protein 2 isoform X4

      UniProtKB/TrEMBL
      B3KPZ6
    2. XM_054376212.1XP_054232187.1  ankyrin repeat and SOCS box protein 2 isoform X2

      UniProtKB/TrEMBL
      B3KPZ6
    3. XM_054376213.1XP_054232188.1  ankyrin repeat and SOCS box protein 2 isoform X3

      UniProtKB/TrEMBL
      B3KPZ6
    4. XM_054376211.1XP_054232186.1  ankyrin repeat and SOCS box protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RDP9, B4E166, Q96Q27, Q9NSU5, Q9Y567
      UniProtKB/TrEMBL
      B3KPZ6
    5. XM_054376215.1XP_054232190.1  ankyrin repeat and SOCS box protein 2 isoform X5

      UniProtKB/TrEMBL
      G3V2Z2
    6. XM_054376216.1XP_054232191.1  ankyrin repeat and SOCS box protein 2 isoform X7

      UniProtKB/TrEMBL
      G3V2Z2