U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CPA4 carboxypeptidase A4 [ Homo sapiens (human) ]

    Gene ID: 51200, updated on 16-Apr-2024

    Summary

    Official Symbol
    CPA4provided by HGNC
    Official Full Name
    carboxypeptidase A4provided by HGNC
    Primary source
    HGNC:HGNC:15740
    See related
    Ensembl:ENSG00000128510 MIM:607635; AllianceGenome:HGNC:15740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPA3
    Summary
    This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in skin (RPKM 24.3) and esophagus (RPKM 4.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    7q32.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (130293161..130324180)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (131606545..131637922)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (129933001..129964020)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129844685-129845484 Neighboring gene serine rich single-pass membrane protein 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129912168-129912820 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129912821-129913472 Neighboring gene Sharpr-MPRA regulatory region 5425 Neighboring gene carboxypeptidase A2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129937306-129937806 Neighboring gene uncharacterized LOC105375503 Neighboring gene small nucleolar RNA U13 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129985848-129986818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129992089-129992735 Neighboring gene carboxypeptidase A5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:130005327-130005828 Neighboring gene uncharacterized LOC105375504 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18645

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-07-25)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-07-25)

    ClinGen Genome Curation Page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metallocarboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metallocarboxypeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in hormone catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptide catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    carboxypeptidase A4
    Names
    carboxypeptidase A3
    NP_001156918.1
    NP_057436.2
    XP_047276394.1
    XP_054214303.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011788.2 RefSeqGene

      Range
      5028..36047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1038

    mRNA and Protein(s)

    1. NM_001163446.2NP_001156918.1  carboxypeptidase A4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001156918.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1. The encoded isoform (2) lacks a portion of the activation peptide and the carboxypeptidase A4 chain, and lacks the intervening cleavage site compared to isoform 1.
      Source sequence(s)
      AC024085
      Consensus CDS
      CCDS55163.1
      UniProtKB/Swiss-Prot
      Q9UI42
      Related
      ENSP00000412947.2, ENST00000445470.6
      Conserved Domains (3) summary
      COG2866
      Location:1370
      MpaA; Murein tripeptide amidase MpaA [Cell wall/membrane/envelope biogenesis]
      pfam02244
      Location:2895
      Propep_M14; Carboxypeptidase activation peptide
      cl11393
      Location:95386
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    2. NM_016352.4NP_057436.2  carboxypeptidase A4 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_057436.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC024085
      Consensus CDS
      CCDS5818.1
      UniProtKB/Swiss-Prot
      B7Z576, Q86UY9, Q9UI42
      UniProtKB/TrEMBL
      A4D1M3
      Related
      ENSP00000222482.4, ENST00000222482.10
      Conserved Domains (2) summary
      cd03870
      Location:118419
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:27101
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      130293161..130324180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420438.1XP_047276394.1  carboxypeptidase A4 isoform X1

      UniProtKB/TrEMBL
      B7Z5J4
      Related
      ENSP00000419660.1, ENST00000493259.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      131606545..131637922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358328.1XP_054214303.1  carboxypeptidase A4 isoform X1

      UniProtKB/TrEMBL
      B7Z5J4