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    Fbxo8 F-box protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 50753, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fbxo8provided by MGI
    Official Full Name
    F-box protein 8provided by MGI
    Primary source
    MGI:MGI:1354696
    See related
    Ensembl:ENSMUSG00000038206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbx8
    Expression
    Ubiquitous expression in adrenal adult (RPKM 8.5), kidney adult (RPKM 7.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Fbxo8 in Genome Data Viewer
    Location:
    8; 8 B2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (57004189..57046974)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (56551154..56593939)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (59029931..59072736)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930518J21 gene Neighboring gene predicted gene, 24375 Neighboring gene centrosomal protein 44 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 pseudogene Neighboring gene VISTA enhancer mm1687

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368347.1NP_001355276.1  F-box only protein 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116121
      Conserved Domains (1) summary
      cd00171
      Location:1155
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    2. NM_001368348.1NP_001355277.1  F-box only protein 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116121
      Conserved Domains (1) summary
      cd00171
      Location:1155
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    3. NM_015791.4NP_056606.2  F-box only protein 8 isoform 1

      See identical proteins and their annotated locations for NP_056606.2

      Status: VALIDATED

      Source sequence(s)
      AC116121
      Consensus CDS
      CCDS22314.1
      UniProtKB/Swiss-Prot
      Q9QZN3
      Related
      ENSMUSP00000037544.6, ENSMUST00000040218.13
      Conserved Domains (2) summary
      cd00171
      Location:133312
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      pfam12937
      Location:74112
      F-box-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      57004189..57046974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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