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    MC5R melanocortin 5 receptor [ Homo sapiens (human) ]

    Gene ID: 4161, updated on 17-Jun-2024

    Summary

    Official Symbol
    MC5Rprovided by HGNC
    Official Full Name
    melanocortin 5 receptorprovided by HGNC
    Primary source
    HGNC:HGNC:6933
    See related
    Ensembl:ENSG00000176136 MIM:600042; AllianceGenome:HGNC:6933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MC2
    Summary
    This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]
    Orthologs
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    Genomic context

    See MC5R in Genome Data Viewer
    Location:
    18p11.21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (13824149..13827323)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (13986528..13989701)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (13824148..13827322)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 210 member A Neighboring gene RNA, 7SL, cytoplasmic 362, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:13725735-13726660 Neighboring gene RNA guanine-7 methyltransferase Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:13775047-13775546 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:13823817-13823997 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13834952-13835452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13872168-13873006 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:13876434-13877404 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr18:13878605-13879337 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13887335-13887847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9337 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13129 Neighboring gene melanocortin 2 receptor Neighboring gene ribosomal protein L36a pseudogene 49

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables melanocortin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005913.3NP_005904.1  melanocortin receptor 5

      See identical proteins and their annotated locations for NP_005904.1

      Status: VALIDATED

      Source sequence(s)
      AP001525, BC069153, DR002771
      Consensus CDS
      CCDS11868.1
      UniProtKB/Swiss-Prot
      B0YJ34, P33032, Q502V1
      Related
      ENSP00000468086.2, ENST00000589410.2
      Conserved Domains (2) summary
      pfam00001
      Location:53295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:43167
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      13824149..13827323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      13986528..13989701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)