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    RGPD1 RANBP2 like and GRIP domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 400966, updated on 3-Apr-2024

    Summary

    Official Symbol
    RGPD1provided by HGNC
    Official Full Name
    RANBP2 like and GRIP domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:32414
    See related
    Ensembl:ENSG00000187627 MIM:612704; AllianceGenome:HGNC:32414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RGP1; RGPD2; RanBP2L2; ranBP2L6
    Summary
    Predicted to contribute to GTPase activator activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 17.9), liver (RPKM 7.1) and 23 other tissues See more
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    Genomic context

    See RGPD1 in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (86913659..87013976)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (86915628..87019191)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (87144738..87241099)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11721 Neighboring gene CD8 subunit alpha Neighboring gene MPRA-validated peak3783 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:87066785-87067341 Neighboring gene CD8 subunit beta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:87083199-87083700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:87083701-87084200 Neighboring gene ANAPC1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:87169373-87170136 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 5 Neighboring gene WBP1 pseudogene 1 Neighboring gene plasminogen like B1 Neighboring gene ANAPC1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11723 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11725 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:87303801-87304306 Neighboring gene tRNA-Pro (anticodon AGG) 4-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ58076

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    RANBP2-like and GRIP domain-containing protein 1
    Names
    RANBP2-like and GRIP domain-containing protein 1/2
    ran-binding protein 2-like 2/6
    ran-binding protein 2-like 6
    ranBP2-like 2/6
    ranBP2-like 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024457.4NP_001019628.3  RANBP2-like and GRIP domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001019628.3

      Status: VALIDATED

      Source sequence(s)
      AC111200, CR749330
      UniProtKB/Swiss-Prot
      P0C839, P0DJD0, Q68DN6, Q6V1X0
      UniProtKB/TrEMBL
      B4DYH0
      Conserved Domains (8) summary
      smart00028
      Location:5182
      TPR; Tetratricopeptide repeats
      COG5171
      Location:9601152
      YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
      cd13177
      Location:10361152
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:13331449
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00006
      Location:5080
      TPR; TPR repeat [structural motif]
      pfam01465
      Location:16901732
      GRIP; GRIP domain
      pfam13414
      Location:50117
      TPR_11; TPR repeat
      pfam16704
      Location:16261686
      Rab_bind; Rab binding domain
    2. NM_001382344.1NP_001369273.1  RANBP2-like and GRIP domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC111200
      Consensus CDS
      CCDS92800.1
      UniProtKB/TrEMBL
      A0A286YES2, B4DYH0
      Related
      ENSP00000492954.1, ENST00000641458.2
      Conserved Domains (7) summary
      smart00028
      Location:5990
      TPR; Tetratricopeptide repeats
      COG0457
      Location:29105
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      cd13177
      Location:10441160
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:13411457
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00006
      Location:5888
      TPR; TPR repeat [structural motif]
      pfam16704
      Location:16341694
      Rab_bind; Rab binding domain
      pfam01465
      Location:16981740
      GRIP; GRIP domain
    3. NM_001410915.1NP_001397844.1  RANBP2-like and GRIP domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC111200
      Consensus CDS
      CCDS92799.1
      UniProtKB/TrEMBL
      F8VYC4
      Related
      ENSP00000381253.3, ENST00000398193.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      86913659..87013976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532845.4XP_011531147.1  RANBP2-like and GRIP domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      B4DYH0
      Conserved Domains (8) summary
      smart00028
      Location:104135
      TPR; Tetratricopeptide repeats
      COG5171
      Location:10131205
      YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
      cd13177
      Location:10891205
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:13861502
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00006
      Location:103133
      TPR; TPR repeat [structural motif]
      pfam01465
      Location:17431785
      GRIP; GRIP domain
      pfam13414
      Location:103170
      TPR_11; TPR repeat
      pfam16704
      Location:16791739
      Rab_bind; Rab binding domain
    2. XM_011532852.4XP_011531154.2  RANBP2-like and GRIP domain-containing protein 1 isoform X5

    3. XM_011532849.4XP_011531151.2  RANBP2-like and GRIP domain-containing protein 1 isoform X2

    4. XM_011532851.4XP_011531153.2  RANBP2-like and GRIP domain-containing protein 1 isoform X4

    5. XM_011532850.3XP_011531152.2  RANBP2-like and GRIP domain-containing protein 1 isoform X3

    RNA

    1. XR_007074605.1 RNA Sequence

    2. XR_007074622.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      86915628..87019191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342033.1XP_054198008.1  RANBP2-like and GRIP domain-containing protein 1 isoform X11

    2. XM_054342028.1XP_054198003.1  RANBP2-like and GRIP domain-containing protein 1 isoform X6

    3. XM_054342029.1XP_054198004.1  RANBP2-like and GRIP domain-containing protein 1 isoform X7

    4. XM_054342031.1XP_054198006.1  RANBP2-like and GRIP domain-containing protein 1 isoform X9

    5. XM_054342030.1XP_054198005.1  RANBP2-like and GRIP domain-containing protein 1 isoform X8

    6. XM_054342032.1XP_054198007.1  RANBP2-like and GRIP domain-containing protein 1 isoform X10

    7. XM_054342034.1XP_054198009.1  RANBP2-like and GRIP domain-containing protein 1 isoform X12