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    Bet1 Blocked early in transport 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40094, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Bet1provided by FlyBase
    Official Full Name
    Blocked early in transport 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0260857
    Locus tag
    Dmel_CG14084
    See related
    AllianceGenome:FB:FBgn0260857
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH40423; BET1; bs16e01.y1; CG14084; Dm Bet1; Dmel\CG14084; G14084
    Summary
    Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Predicted to be integral component of Golgi membrane. Predicted to be part of SNARE complex. Predicted to be active in Golgi trans cisterna. Is expressed in adult head. Orthologous to human BET1 (Bet1 golgi vesicular membrane trafficking protein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    76A3-76A3; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19261394..19262437)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19254494..19255537)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene reptin Neighboring gene nessy Neighboring gene antisense RNA:CR45210 Neighboring gene Max Neighboring gene uncharacterized protein Neighboring gene Methyltransferase like 5 Neighboring gene uncharacterized protein Neighboring gene Aldehyde dehydrogenase 7 family member A1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo profiling of the Zucchini proximal proteome in the Drosophila ovary. Nguyen TTM, et al. Development, 2023 Feb 15. PMID 36762624
    2. The ROP vesicle release factor is required in adult Drosophila glia for normal circadian behavior. Ng FS, et al. Front Cell Neurosci, 2015. PMID 26190976, Free PMC Article
    3. SNAREing the basis of multicellularity: consequences of protein family expansion during evolution. Kloepper TH, et al. Mol Biol Evol, 2008 Sep. PMID 18621745
    4. Identification of two pathways mediating protein targeting from ER to lipid droplets. Song J, et al. Nat Cell Biol, 2022 Sep. PMID 36050470, Free PMC Article
    5. A genome-wide RNAi screen identifies regulators of cholesterol-modified hedgehog secretion in Drosophila. Aikin R, et al. PLoS One, 2012. PMID 22432040, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables syntaxin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle fusion with Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    blocked early in transport 1
    Names
    BET1 ortholog
    Bet1-PA
    Bet1-PB
    CG14084-PA
    CG14084-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19261394..19262437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168789.5 → NP_730391.1  blocked early in transport 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730391.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVX6
      Related
      FBpp0074758
      Conserved Domains (2) summary
      cd15853
      Location:38 → 85
      SNARE_Bet1; SNARE motif of Bet1
      pfam05739
      Location:65 → 111
      SNARE; SNARE domain

    2. NM_140839.4 → NP_649096.1  blocked early in transport 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649096.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVX6
      Related
      FBpp0074757
      Conserved Domains (2) summary
      cd15853
      Location:38 → 85
      SNARE_Bet1; SNARE motif of Bet1
      pfam05739
      Location:65 → 111
      SNARE; SNARE domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVX6 Q9VVX6

    Gene LinkOut

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