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    GAPcenA GTPase activating protein and centrosome-associated [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38945, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GAPcenAprovided by FlyBase
    Official Full Name
    GTPase activating protein and centrosome-associatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035879
    Locus tag
    Dmel_CG7112
    See related
    AllianceGenome:FB:FBgn0035879
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7112; Dmel\CG7112; FBgn 35879; FBgn0035879; GapcenA
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in cytosol. Orthologous to several human genes including RABGAP1L (RAB GTPase activating protein 1 like). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    66C8-66C8; 3-24 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8346561..8352279)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8339661..8345379)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene DNA primase subunit 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene CUB and LDLa domain Neighboring gene mir-4913 stem loop Neighboring gene Isocitrate dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity. Yao Y, et al. Elife, 2015 Mar 4. PMID 25738228, Free PMC Article
    2. Competition within Introns: Splicing Wins over Polyadenylation via a General Mechanism. Tikhonov M, et al. Acta Naturae, 2013 Oct. PMID 24455183, Free PMC Article
    3. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
    4. Some novel intron positions in conserved Drosophila genes are caused by intron sliding or tandem duplication. Lehmann J, et al. BMC Evol Biol, 2010 May 26. PMID 20500887, Free PMC Article
    5. Evi5 promotes collective cell migration through its Rab-GAP activity. Laflamme C, et al. J Cell Biol, 2012 Jul 9. PMID 22778279, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    GTPase activating protein and centrosome-associated
    Names
    CG7112-PA
    CG7112-PB
    GAPcenA-PA
    GAPcenA-PB
    GTPase activating protein and centrosome-associated ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8346561..8352279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104079.4 → NP_001097549.1  GTPase activating protein and centrosome-associated, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097549.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNN5, Q8MT33
      Conserved Domains (4) summary
      smart00164
      Location:650 → 858
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:204 → 332
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam10669
      Location:914 → 991
      Phage_Gp23; Protein gp23 (Bacteriophage A118)
      pfam12473
      Location:429 → 523
      DUF3694; Kinesin protein

    2. NM_139956.1 → NP_648213.1  GTPase activating protein and centrosome-associated, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT33, Q9VSI2
      Related
      FBpp0076332, FBtr0076605
      Conserved Domains (4) summary
      smart00164
      Location:514 → 722
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:68 → 196
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam10669
      Location:778 → 855
      Phage_Gp23; Protein gp23 (Bacteriophage A118)
      pfam12473
      Location:293 → 387
      DUF3694; Kinesin protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNN5 A8JNN5
    Q8MT33 Q8MT33
    Q9VSI2 Q9VSI2

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